My research centers around the role of the vesicular nucleotide transporter (VNUT) in glial cells in modulating central monoamine release in real time. Purinergic signaling via VNUT is thought to play an important role on how glial insulin receptors regulate monoamine exocytosis. In addition, I screen preclinical drug candidates that may impact on central monoamine exocytosis via mechanisms equivalent to the one described above. I am also performing in-vitro incubations of uridine 5'-diphospho-glucuronosyltransferase enzymes (UGTs) using human liver microsomes (HLM) to evaluate potential drug-drug interactions caused by inhibition or induction of these enzymes. One of the drugs I am currently focusing on is isosorbide 5-mononitrate, a cardiovascular drug to treat heart failure with preserved ejection fraction (HFpEF).