Epilepsy is one of the most common chronic neurological disorders, affecting 1% of the population world-wide. Despite advances in pharmacological and surgical methods of reducing seizures in epilepsy, the mechanisms that cause epilepsy remain poorly understood and there are no definitive treatments. For example, 30% of patients with epilepsy have uncontrolled seizures, despite multiple pharmacological interventions. Thus, understanding molecular mechanisms mediating epileptogenesis is critical for developing more effective therapies for epilepsy. The Yee lab has identified a correlation between epileptogenesis and Wnt signaling. My thesis is analyzing a genetic model of Wnt-signaling-induced epilepsy with correlates in human disease. We are examining a combinational drug therapy that both crosses the blood-brain barrier and suppresses Wnt signaling as an intervention in the epileptogenic process.