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Graduate School of Biomedical Sciences

Sirisha Mukkavalli

Postdoctoral Scholar

Sirisha Mukkavalli

Sirisha Mukkavalli

Postdoctoral Scholar

Education: 
BTech, Biotechnology, Jawaharlal Nehru Technological University, Hyderabad, India
MS, Biomedical Engineering & Biotechnology, University of Massachusetts - Dartmouth, Dartmouth, MA
PhD, Biomedical Engineering & Biotechnology, University of Massachusetts - Dartmouth, Dartmouth, MA
Research synopsis: 

Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disorder characterized by the prevalence of ubiquitin positive cellular aggregates, termed stress granules. A significant number of ALS causative genes including valosin containing protein (VCP), are linked to stress granule proteins and mutations result in the accelerated formation of stress granules. VCP mutations that cause ALS have been reported to interfere stress granule disassembly by autophagy, however the mechanisms that govern this important process are poorly understood. The goal of my work is to unravel the relationship between VCP and the stress granule life cycle.

Advisor: