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Graduate School of Biomedical Sciences

Recent Publications from the Zeng Lab

Uchimura T, Nakamura DS, Link EM, Noguchi Y, Ōmura S, Sunazuka T, Greenblatt DJ, Zeng L. 2019. Erythromycin acts through the ghrelin receptor to attenuate inflammatory responses in chondrocytes and maintain joint integrity. Biochem Pharmacol. Epub ahead of print. Abstract

p>Hollander JM, Zeng L. 2019. The emerging role of glucose metabolism in cartilage development. Curr Osteoporos Rep. Eupb ahead of print. Abstract

Hui Mingalone CK, Liu Z, Hollander JM, Garvey KD, Gibson AL, Banks RE, Zhang M, McAlindon TE, Nielsen HC, Georgakoudi I, Zeng L. 2018. Bioluminescence and second harmonic generation imaging reveal dynamic changes in the inflammatory and collagen landscape in early osteoarthritis. Lab Invest. Epub ahead of print. Abstract

Uchimura T, Hollander JM, Nakamura DS, Liu Z, Rosen CJ, Georgakoudi I, Zeng L. 2017. An essential role for IGF2 in cartilage development and glucose metabolism during postnatal long bone growth. Development 144: 3533-3546. Abstract

Gibson AL, Hui Mingalone CK, Foote AT, Uchimura T, Zhang M, Zeng L. 2017. Wnt7a inhibits IL-1β induced catabolic gene expression and prevents articular cartilage damage in experimental osteoarthritis. Sci Rep. 7: 41823.  Abstract

Nakamura DS, Hollander JM, Uchimura T, Nielsen HC, Zeng L. 2017. Pigment epithelium-derived factor (PEDF) mediates cartilage matrix loss in an age-dependent manner under inflammatory conditions. BMC Musculoskelet Disord. 18: 39.  Abstract

Liu Z, Pouli D, Sood D, Sundarakrishnan A, Hui Mingalone CK, Arendt LM, Alonzo C, Quinn KP, Kuperwasser C, Zeng L, Schnelldorfer T, Kaplan DL, Georgakoudi I. 2016. Automated quantification of three-dimensional organization of fiber-like structures in biological tissues. Biomaterials 116: 34-47.  Abstract

Uchimura T, Foote AT, Markel DC, Ren W, Zeng L. 2016. The chondroprotective role of erythromycin in a murine joint destruction model. Cartilage 7(4):373-387. Abstract

Tang X, Fan l, Pei M, Zeng L, Zigang G. 2015. Evolving concepts of chondrogenic differentiation: History, state-of-art and future perspectives. Eur Cell Mater. 30: 12-27. Abstract

Uchimura T, Foote AT, Smith EL, Matzkin EG, Zeng L. 2015. Insulin-like growth factor II (IGF-II) inhibits IL-1β-induced cartilage matrix loss and promotes cartilage integrity in experimental osteoarthritis. J Cell Biochem. 116: 2858-2869. Abstract

Leahy AA, Esfahani SA, Foote AT, Hui CK, Rainbow RS, Nakamura DS, Tracey BH, Mahmood U, Zeng L. 2015. Following the trajectory of osteoarthritis development through serial near infrared fluorescence imaging of MMP activities. Arthritis Rheumatol. 67: 442-453. Abstract

Rainbow RS, Kwon H and Zeng L. 2014. Role of Nkx3.2 in chondrogenesis. Front Biol. 9: 376-387. Abstract

Kwon H, Rainbow RS, Sun L, Hui CK, Cairns DM, Preda RC, Kaplan DL, Zeng L. 2014. Scaffold structure and fabrication method affect pro-inflammatory milieu in 3D-cultured chondrocytes. J Biomed Mater Res A 103: 534-544. Abstract

Cairns DM, Pignolo RJ, Uchimura T, Brennan TA, Lindborg CM, Xu M, Kaplan FS, Shore EM, Zeng L.. 2013. Somitic disruption of GNAS in chick embryos mimics progressive osseous heteroplasia. J Clin Invest. 123: 3624-3633. Abstract

Rainbow RS, Kwon H, Foote AT, Preda RC, Kaplan DL, Zeng L. 2013. Muscle cell-derived factors inhibit inflammatory stimuli-induced damage in hMSC-derived chondrocytes. Osteoarthritis Cartilage. 21: 990-998. Abstract

Kwon H, Sun L, Cairns DM, Rainbow RS, Preda RC, Kaplan DL, Zeng L. 2013. The influence of scaffold material on chondrocytes in inflammatory conditions. Acta Biomater. 9: 6563-6575. Abstract