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Graduate School of Biomedical Sciences

Recent Publications from the Theoharides Lab

Bawazeer MA, Theoharides TC. 2019. IL-33 stimulates human mast cell release of CCL5 and CCL2 via MAPK and NF-κB, inhibited by methoxyluteolin. Eur J Pharmacol. 26:172760. doi: 10.1016/j.ejphar.2019.172760. Abstract

Tsilioni I, Patel AB, Pantazopoulos H, Berretta S, Conti P, Leeman SE, Theoharides TC. 2019. IL-37 is increased in brains of children with autism spectrum disorder and inhibits human microglia stimulated by neurotensin. Proc Natl Acad Sci USA Epub ahead of print. Abstract

Tellechea A, Bai S, Dangwal S, Theocharidis G, Nagai M, Koerner S, Cheong JE, Bhasin S, Shih TY, Zheng Y, Zhao W, Zhang C, Li X, Kounas K, Panagiotidou S, Theoharides T, Mooney D, Bhasin M, Sun L, Veves A. 2019. Topical application of a mast cell stabilizer improves impaired diabetic wound healing. J Invest Dermatol. pii: S0022-202X(19)33240-3. doi: 10.1016/j.jid.2019.08.449. Abstract

Lonergan A, Theoharides T, Tsilioni E, Rebeiz E. 2019. Substance P and Hemokinin 1 in nasal lavage fluid of patients with chronic sinusitis and nasal polyposis. OTO Open 3(3):2473974X19875076. doi: 10.1177/2473974X19875076. Abstract

Almehmadi KA, Tsilioni I, Theoharides TC. 2019. Increased expression of miR-155p5 in amygdala of children with autism spectrum disorder. Autism Res. doi: 10.1002/aur.2205. Abstract

Ren HL, Li JD, Yue FS, Sun JL, Rebeiz EE, Theoharides TC. 2019. Nasal cytology with emphasis on mast cells can improve the diagnosis and treatment of chronic rhinosinusitis. Chin Med J Epub ahead of print. Abstract

Theoharides TC, Tsilioni I, Bawazeer M. 2019. Mast cells, neuroinflammation and pain in fibromyalgia syndrome. Front Cell Neurosci. 13:353. doi: 10.3389/fncel.2019.00353. Abstract

Theoharides TC, Kavalioti M, Tsilioni I. 2019. Mast cells, stress, fear and autism spectrum disorder. Int J Mol Sci. 20(15). pii: E3611. Abstract

Theoharides TC, Tsilioni I, Conti P. 2019. Mast cells may regulate the anti-inflammatory activity of IL-37. Int J Mol Sci. 20(15). pii: E3701. Abstract

Tsilioni I, Pipis H, Freitag MSC, Izquierdo MDC, Freitag K, Theoharides TC. 2019. Effects of an extract of salmon milt on symptoms and serum TNF and Substance P in patients With fibromyalgia syndrome. Clin Ther. Epub ahead of print. Abstract

Theoharides TC, Kavalioti M. 2019. Effect of stress on learning and motivation-relevance to autism spectrum disorder. Int J Immunopathol Pharmacol. 33:2058738419856760. Abstract

Antonopoulos D, Tsilioni I, Balatsos NAA, Gourgoulianis KI, Theoharides TC. 2019. The mast cell - neurofibromatosis connection. J Biol Regul Homeost Agents. 33: 657-659. Abstract

Kounis NG, Ren HL, Kavalioti M, Koniari I, Theoharides TC. 2019. Intimate contact could be dangerous for your health. Clin Ther. 41: 796-797. Abstract

Theoharides TC. 2019. In search of effective treatments for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Clin Ther. 41: 796-797. Abstract

Conti P, Theoharides TC. 2019. IgE and macrophages for cancer rescue? EBioMedicine 43: 7-8. Abstract

Theoharides TC. 2019. A timely multidisciplinary update on myalgic encephalomyelitis/chronic fatigue syndrome. Clin Ther. 41: 610-611. Abstract

Theoharides TC, Tsilioni I, Ren H. 2019. Recent advances in our understanding of mast cell activation - or should it be mast cell mediator disorders? Expert Rev Clin Immunol. 15: 639-656. Abstract

Gross AR, Theoharides TC. 2019. Chondroitin sulfate inhibits secretion of TNF and CXCL8 from human mast cells stimulated by IL-33. Biofactors 45: 49-61. Abstract

Therianou A, Vasiadi M, Delivanis DA, Petrakopoulou T, Katsarou-Katsari A, Antoniou C, Stratigos A, Tsilioni I, Katsambas A, Rigopoulos D, Theoharides TC. 2019. Mitochondrial dysfunction in affected skin and increased mitochondrial DNA in serum from patients with psoriasis. Exp Dermatol. 28: 72-75. Abstract

Theoharides TC, Leeman SE. 2019. Effect of IL-33 on de novo synthesized mediators from human mast cells. J Allergy Clin Immunol. 143:451. Abstract

Conti P, Caraffa A, Mastrangelo F, Tettamanti L, Ronconi G, Frydas I, Kritas SK, Theoharides TC. 2018. Critical role of inflammatory mast cell in fibrosis: Potential therapeutic effect of IL-37. Cell Prolif. 51:e12475. Abstract

Theoharides TC, Tsilioni I. 2018. Tetramethoxyluteolin for the treatment of neurodegenerative diseases. Curr Top Med Chem 18: 1872-1882. Abstract

Theoharides TC, Kavalioti M. 2018. Stress, inflammation and natural treatments. J Biol Regul Homeost Agents. 32: 1345-1347. Abstract

Theoharides TC, Tsilioni I. 2018. Tetramethoxyluteolin for the treatment of neurodegenerative diseases. Curr Top Med Chem. 18: 1872-1882. Abstract

Taracanova A, Tsilioni I, Conti P, Norwitz ER, Leeman SE, Theoharides TC. 2018. Substance P and IL-33 administered together stimulate a marked secretion of IL-1β from human mast cells, inhibited by methoxyluteolin. Proc Natl Acad Sci USA. 115: E9381-E9390. Abstract

Tsilioni I, Theoharides TC. 2018. Extracellular vesicles are increased in the serum of children with autism spectrum disorder, contain mitochondrial DNA, and stimulate human microglia to secrete IL-1β. J Neuroinflammation. 15: 239. Abstract

Hatziagelaki E, Adamaki M, Tsilioni I, Dimitriadis G, Theoharides TC. 2018. Myalgic encephalomyelitis/chronic fatigue syndrome-metabolic disease or disturbed homeostasis? J Pharmacol Exp Ther. 367: 155-167. Abstract

Conti P, Caraffa A, Mastrangelo F, Tettamanti L, Ronconi G, Frydas I, Kritas SK, Theoharides TC. 2018. Critical role of inflammatory mast cell in fibrosis: Potential therapeutic effect of IL-37. Cell Prolifer. 30: e12475. Abstract

Conti P, Caraffa A, Ronconi G, Kritas SK, Mastrangelo F, Tettamanti L, Frydas I, Theoharides TC. 2018. Mast cells participate in allograft rejection: can IL-37 play an inhibitory role? Inflamm Res. 67: 747-755. Abstract

Conti P, Caraffa A, Ronconi G, Conti CM, Kritas SK, Mastrangelo F, Tettamanti L, Theoharides TC. 2018. Impact of mast cells in depression disorder: inhibitory effect of IL-37 (new frontiers). Immunol. Res. Epub ahead of print. Abstract

King L, Tsilioni I, Theoharides TC. 2018. Time to look past TNF and thalidomide for cachexia - could mast cells and flavonoids be the answer? J Biol Regul Homeost Agents 32: 443-447.  Abstract

Ratnaseelan AM, Tsilioni I, Theoharides TC. 2018. Effects of mycotoxins on neuropsychiatric symptoms and immune processes. Clin Ther. 40: 903-917.  Abstract

Petra AI, Tsilioni I, Taracanova A, Katsarou-Katsari A, Theoharides TC. 2018. Interleukin 33 and interleukin 4 regulate interleukin 31 gene expression and secretion from human laboratory of allergic diseases 2 mast cells stimulated by substance P and/or immunoglobulin E. Allery Asthma Proc. 39: 153-160.  Abstract

Patel AB, Tsilioni I, Weng Z, Theoharides TC. 2018. TNF stimulates IL-6, CXCL8 and VEGF secretion from human keratinocytes via activation of mTOR, inhibited by tetramethoxyluteolin. Exp Dermatol. 27: 135-143.  Abstract

Conti P, Caraffa A, Ronconi G, Kritas SK, Mastrangelo F, Tettamanti L, Theoharides TC. 2018. Impact of mast cells in mucosal immunity of intestinal inflammation: Inhibitory effect of IL-37. Eur J Pharmacol. 818: 294-299.  Abstract

Conti P, Carinci F, Caraffa A, Ronconi G, Lessiani G, Theoharides TC. 2017. Link between mast cells and bacteria: Antimicrobial defense, function and regulation by cytokines. Med Hypotheses 106: 10-14.  Abstract

Conti P, Carinci F, Lessiani G, Spinas E, Kritas SK, Ronconi G, Caraffa A, Theoharides TC. 2017. Potential therapeutic use of IL-37: a key suppressor of innate immunity and allergic immune responses mediated by mast cells. Immunol Res. 65: 982-986.   Abstract

Conti P, Caraffa A, Kritas SK, Ronconi G, Lessiani G, Toniato E, Theoharides TC. 2017. Mast cell, pro-inflammatory and anti-inflammatory: Jekyll and Hyde, the story continues. J Biol Regul Homeost Agents 31: 263-267.   Abstract

Patel AB, Theoharides TC. 2017. Methoxyluteolin inhibits neuropeptide-stimulated proinflammatory mediator release via mTOR activation from human mast cells. J Pharmaol Exp Ther. 361: 462-471.   Abstract

Theoharides TC. 2017. Vitamin D and atopy. Clin Ther. 39: 880-883.  Abstract

Taracanova A, Alevizos M, Karagkouni A, Weng Z, Norwitz E, Conti P, Leeman SE, Theoharides TC. 2017. SP and IL-33 together markedly enhance TNF synthesis and secretion from human mast cells mediated by the interaction of their receptors. Proc Natl Acad Sci USA 114: E4002-E4009.  Abstract

Conti P, Lessiani G, Kritas SK, Ronconi G, Caraffa A, Theoharides TC. 2017. Mast cells emerge as mediators of atherosclerosis: Special emphasis on IL-37 inhibition. Tissue Cell  49: 393-400. Abstract

Theoharides TC. 2017. Neuroendocrinology of mast cells: Challenges and controversies. Exp Dermatol. 26: 751-759.   Abstract

Patel AB, Tsilioni I, Leeman SE, Theoharides TC. 2016. Neurotensin stimulates sortilin and mTOR in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism. Proc Natl Acad Sci USA 113: E7049–E7058.   Abstract

Palaska I, Gagari E, Theoharides TC. 2016. The effects of P. gingivalis and E. coli LPS on the expression of proinflammatory mediators in human mast cells and their relevance to periodontal disease. J Biol Regul Homeost Agents. 30: 655-664.  Abstract

Theoharides TC, Tsilioni I, Patel AB, Doyle R. 2016. Atopic diseases and inflammation of the brain in the pathogenesis of autism spectrum disorders. Transl Psychiatry. 6: e844.  Abstract

Caraffa A, Spinas E, Kritas SK, Lessiani G, Ronconi G, Saggini A, Antinolfi P, Pizzicannella J, Toniato E, Theoharides TC, Conti P. 2016. Endocrinology of the skin: intradermal neuroimmune network, a new frontier. J Biol Regul Homeost Agents 30: 349-353.   Abstract

Theoharides TC, Stewart JM, Taracanova A, Conti P, Zouboulis CC. 2016. Neuroendocrinology of the skin. Rev Endocr Meab Disorders Epub ahead of print.  Abstract

Tellechea A, Leal EC, Kafanas A, Auster ME, Kuchibhotla S, Ostrovsky Y, Tecilazich F, Baltzis D, Zheng Y, Carvalho E, Zabolotny JM, Weng Z, Petra A, Patel A, Panagiotidou S, Pradhan-Nabzdyk L, Theoharides TC, Veves A. 2016. Mast cells regulate wound healing in diabetes. Diabetes 65: 2006-2019.  Abstract

Weng Z, Zhang B, Tsilioni I, Theoharides TC. 2016. Nanotube formation: A rapid form of "alarm signaling"? Clin Ther. pii: S0149-2918(16)30127-8.  Abstract

Theoharides, TC. 2016. Danger signals and inflammation. Clin Ther. pii: S0149-2918(16)30182-5.  Abstract

Theoharides TC, Stewart JM. 2016. Post-Lyme syndrome-associated polyneuropathy treated with immune immunoglobulin and a luteolin-containing formulation. J Clin Pharmacol. 36: 290-291.   Abstract

Theoharides TC. 2016. Skin mast cells: Are we missing the forest for the trees? Exp Dermatol. 25: 422-423.   Abstract

Theoharides TC, Stewart JM. 2016. Antihistamines and mental status. J Clin Pharmacol. 36: 195-197.   Abstract

Tsilioni I, Russell IJ, Stewart JM, Gleason RM, Theoharides TC. 2016. Substance P, Hemokinin-1, CRH, TNF and IL-6 are increased in serum of patients with Fibromyalgia Syndrome and may serve both as biomarkers and targets for treatment. J Pharmacol Exp Ther. 356: 664-672.   Abstract

Tsilioni I, Taliou A, Francis K, Theoharides TC. 2015. Children with autism spectrum disorders, who improved with a luteolin-containing dietary formulation, show reduced serum levels of TNF and IL-6. Transl Psychiatry. 5: e647.  Abstract

Polyzoidis S, Koletsa T, Panagiotidou S, Ashkan K, Theoharides TC 2015. Mast cells in meningiomas and brain inflammation. J Neuroinflammation 12: 170. Abstract

Theoharides TC, Tsilioni I, Arbetman L, Panagiotidou S, Stewart JM, Gleason RM, Russell IJ. 2015. Fibromyalgia, a syndrome in search of pathogenesis and therapy. J Pharmacol Exp Ther. 355: 255-263.  Abstract

Theoharides TC, Stewart JM. 2015. Genitourinary mast cells and survival. Transl Androl Urol. 4: 579-586.  Abstract

Theoharides TC, Valent P, Akin C. 2015. Mast Cells, mastocytosis, and related disorders. N Engl J Med. 373: 163-72. Abstract

Theoharides TC, Stewart JM, Hatziagelaki E, Kolaitis G. 2015. Brain "fog," inflammation and obesity: key aspects of neuropsychiatric disorders improved by luteolin. Front Neurosci. 9: 225.  Abstract

Petra AI, Panagiotidou S, Hatziagelaki E, Stewart JM, Conti P, Theoharides TC. 2015. Gut-microbiota-brain axis and Its effect on neuropsychiatric disorders with suspected immune dysregulation. Clin Ther. 37: 984-995. Abstract

Theoharides TC. 2015. On the gut microbiome-brain axis and altruism. Clin Ther. 37: 937-940.  Abstract

Theoharides TC, Petra AI, Taracanova A, Panagiotidou S, Conti P. 2015. Targeting IL-33 in autoimmunity and inflammation. J Pharmacol Exp Ther. 354: 24-31. Abstract

Theoharides TC, Stewart JM, Panagiotidou S, Melamed I. 2015. Mast cells, brain inflammation and autism. Eur J Pharmacol. 778: 96-102. Abstract

Theoharides TC. 2015. Mast cells promote malaria infection? Clin Ther. 37: 1374-1377. Abstract

Theoharides TC, Athanassiou M, Panagiotidou S, Doyle R. 2015. Dysregulated brain immunity and neurotrophin signaling in Rett syndrome and autism spectrum disorders. J Nueroimmunol. 279C: 33-38. Abstract