Skip to main content
Graduate School of Biomedical Sciences

Recent Publications from the Reagan Lab

Ham J, Lever L, Fox M, Reagan MR. 2019. In vitro 3D cultures to reproduce the bone marrow niche. JBMR Plus 3(10):e10228. doi: 10.1002/jbm4.10228. Abstract

Costa S, Reagan MR. 2019. Therapeutic irradiation: Consequences for bone and bone marrow adipose tissue. Front Endocrinol 10:587. Abstract

Falank C, Tasset AW, Farrell M, Harris S, Everill P, Marinkovic M, Reagan MR. 2019. Development of medical-grade, discrete, multi-walled carbon nanotubes as drug delivery molecules to enhance the treatment of hematological malignancies. Nanomedicine 3: 102025. Abstract

Costa S, Fairfield H, Reagan MR 2019. Inverse correlation between trabecular bone volume and bone marrow adipose tissue in rats treated with osteoanabolic agents. Bone 123: 211-223. Abstract

Masarwi M, DeSchiffart A, Ham J, Reagan MR. 2019. Multiple myeloma and fatty acid metabolism. JBMR Plus. 3: e10173. Abstract

Harmer D, Falank C, Reagan MR. 2019. Interleukin-6 interweaves the bone marrow microenvironment, bone loss, and multiple myeloma. Front Endocrinol. 9:788. Abstract

Tsukamoto S, Løvendorf MB, Park J, Salem KZ, Reagan MR, Manier S, Zavidij O, Rahmat M, Huynh D, Takagi S, Kawano Y, Kokubun K, Thrue CA, Nagano K, Petri A, Roccaro AM, Capelletti M, Baron R, Kauppinen S, Ghobrial IM. 2018. Inhibition of microRNA-138 enhances bone formation in multiple myeloma bone marrow niche. Leukemia 32: 1739-1750. Abstract

Farrell ML, Reagan MR. 2018. Soluble and cell-cell-mediated drivers of proteasome inhibitor resistance in multiple myeloma. Front Endocrinol. 9:218. Abstract

Sitarski AM, Fairfield H, Falank C, Reagan MR. 2018. 3d tissue engineered in vitro models of cancer in bone. ACS Biomater Sci Eng. 4: 324-336. Abstract

Fairfield H, Falank C, Farrell M, Vary C, Boucher JM, Driscoll H, Liaw L, Rosen CJ, Reagan MR. 2019. Development of a 3D bone marrow adipose tissue model. Bone 118:77-88. Abstract

Falank C, Fairfield H, Reagan MR. 2017. Reflections on cancer in the bone marrow: Adverse roles of adipocytes. Curr Mol Biol Rep. 3: 254-262. Abstract

Fairfield H, Falank C, Harris E, Demambro V, McDonald M, Pettitt JA, Mohanty ST, Croucher P, Kramer I, Kneissel M, Rosen CJ, Reagan MR. 2018. The skeletal cell-derived molecule sclerostin drives bone marrow adipogenesis. J Cell Physiol. 233: 1156-1167. Abstract

Bornstein S, Moschetta M, Kawano Y, Sacco A, Huynh D, Brooks D, Manier S, Fairfield H, Falank C, Roccaro AM, Nagano K, Baron R, Bouxein M, Vary C, Ghobrial IM, Rosen CJ, Reagan MR. 2017. Bone marrow stroma and vascular contributions to myeloma bone homing. Curr Osteoporos Rep. 15: 499-506 Abstract

Fairfield H, Rosen CJ, Reagan MR. 2017. Connecting bone and fat: The potential role for sclerostin. Curr Mol Biol Rep. 3: 114-121 Abstract

Liu P, Ji Y, Yuen T, Rendina-Ruedy E, DeMambro VE, Dhawan S, Abu-Amer W, Izadmehr S, Zhou B, Shin AC, Latif R, Thangeswaran P, Gupta A, Li J, Shnayder V, Robinson ST, Yu YE, Zhang X, Yang F, Lu P, Zhou Y, Zhu LL, Oberlin DJ, Davies TF, Reagan MR, Brown A, Kumar TR, Epstein S, Iqbal J, Avadhani NG, New MI, Molina H, van Klinken JB, Guo EX, Buettner C, Haider S, Bian Z, Sun L, Rosen CJ, Zaidi M. 2017. Blocking FSH induces thermogenic adipose tissue and reduces body fat. Nature 546: 107-112. Abstract

McDonald MM, Reagan MR, Youlten SE, Mohanty ST, Seckinger A, Terry RL, Pettitt JA, Simic MK, Cheng TL, Morse A, Le LMT, Abi-Hanna D, Kramer I, Falank C, Fairfield H, Ghobrial IM, Baldock PA, Little DG, Kneissel M, Vanderkerken K, Bassett JHD, Williams GR, Oyajobi BO, Hose D, Phan TG, Croucher PI. 2017. Inhibiting the osteocyte-specific protein sclerostin increases bone mass and fracture resistance in multiple myeloma. Blood 129: 3452-3464. Abstract

Sacco A, Kawano Y, Moschetta M, Zavidij O, Huynh D, Reagan M, Mishima Y, Manier S, Park J, Morgan E, Takagi S, Wong KK, Carrasco R, Ghobrial IM, Roccaro AM. 2017. A novel in vivo model for studying conditional dual loss of BLIMP-1 and p53 in B-cells, leading to tumor transformation. Am J Hematol. 92: E138-E145. Abstract

Soley L, Falank C, Reagan MR. 2017. MicroRNA transfer between bone marrow adipose and multiple myeloma cells. Curr Osteoporos Rep. 15: 162-170. Abstract

Reagan MR, Lian JB, Rosen CJ, Stein GS. 2017. A perspective on malignancy in the marrow. J Cell Physiol. 232: 3218-3220. Abstract

Bar-Natan M, Stroopinsky D, Luptakova K, Coll MD, Apel A, Rajabi H, Pyzer AR, Palmer K, Reagan MR, Nahas MR, Karp Leaf R, Jain S, Arnason J, Ghobrial IM, Anderson KC, Kufe D, Rosenblatt J, Avigan D. 2017. Bone marrow stroma protects myeloma cells from cytotoxic damage via induction of the oncoprotein MUC1. Br J Haematol. 176: 929-938. Abstract

McDonald MM, Fairfield H, Falank C, Reagan MR. 2017. Adipose, bone, and myeloma: Contributions from the microenvironment. Calcif Tissue Int. 100: 433-448. Abstract