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Graduate School of Biomedical Sciences

Recent Publications from the Oudin Lab

Oudin MJ, Weaver VM. 2017. Physical and chemical gradients in the tumor microenvironment regulate tumor cell invasion, migration, and metastasis. Cold Spring Harbor Symp Quant Biol. 2017 Apr 19. pii: 030817. doi: 10.1101/sqb.2016.81.030817. Abstract

Oudin MJ & Gertler FB (2017) Signatures of breast cancer metastasis: aMENAble to interpretation? Trends Cancer 3: 7-9.  Abstract

Oudin MJ, Barbier L, Schäfer C, Kosciuk T, Miller MA, Han S, Jonas O, Lauffenburger DA, Gertler FB. 2017. Mena confers resistance to paclitaxel in triple-negative breast cancer. Mol Cancer Ther. 16: 143-155. Abstract

Oudin MJ, Miller MA, Klazen JAZ, Kosciuk T, Lussiez A, Hughes SK, Tadros J, Bear JE, Lauffenburger DA, Gertler FB. 2016. MenaINV mediates synergistic crosstalk between the pathways regulating chemotaxis and haptotaxis. Mol Biol Cell 27: 3085-3094.  Abstract

Jonas O, Oudin MJ, Kosciuk T, Whitman M, Gertler FB, Cima MJ, Flaherty K, Langer R. 2016. Parallel in vivo assessment of drug phenotypes at various time points during systemic BRAF inhibition reveals tumor adaptation and altered treatment vulnerabilities. Clin Cancer Res. 6: 516-531. Abstract

Miller MA*, Oudin MJ*, Sullivan RJ, Wang SJ, Meyer AS, Im H, Frederick DT, Tadros J, Griffith LG, Lee H, Weissleder R, Flaherty K, Gertler FB, Lauffenburger DA. 2016. Reduced proteolytic shedding of receptor tyrosine kinases is a post-translational mechanism of kinase inhibitor resistance. Cancer Discov. 6: 382-399 * Equal contribution. Abstract

Oudin MJ, Hughes SK, Rohani N, Moufarrej MN, Jones JG, Condeelis JS, Lauffenburger DA, Gertler FB. 2016. Characterization of MenaINV expression during tumor progression. Clin Exp Metastasis 33: 249-261. Abstract

Oudin MJ, Jonas O, Kosciuk T, Broye LC, Guido B, Wyckoff J, Lamar JM, Riquelme DN, Asokan SB, Ma D, Whittaker C, Langer R, Cima MJ, Wasinski KB, Lauffenburger DA, Keely PJ, Bear JE, Gertler FB. 2016. Tumor-cell driven extracellular matrix remodeling drives haptotaxis during metastatic progression.Cancer Discov. 6: 516-531. Abstract

​Li CM, Gocheva V, Oudin MJ, Bhutkar A, Wang SY, Ng SR, Whittaker C, Bronson R, Snyder E, Gertler FB, Jacks T. 2015. Foxa2 and Cdx2 synergize with Nkx2-1 to limit metastasis of lung adenocarcinoma. Genes Dev. 29: 1850-1862.  Abstract

Hughes SK*, Oudin MJ*, Tadros J, Moufarrej MN, Neil J, Del Rosario A, Joughin B, Ritsma L, Wyckoff J, Lussiez A, Condeelis J, van Rheenen J, White F, Lauffenburger D, Gertler FB. 2015. Regulation of receptor tyrosine kinase signaling by the actin binding protein Mena. Mol Biol Cell 26: 3867-3878.  *Equal contribution Abstract

Zhou Y, Oudin MJ, Gajendra S, Sonego M, Falenta K, Williams G, Lalli G, Doherty P. 2015. Regional effects of endocannabinoid, BDNF and FGF receptor signalling on neuroblast motility and guidance along the rostral migratory stream. Mol Cell Neurosci. 64: 32-43. Abstract