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Graduate School of Biomedical Sciences

Recent Publications from the Moore Lab

Pearson EL, Graber JH, Lee SD, Naggert KS, Moore CL. 2019. Ipa1 is an RNA polymerase II elongation factor that facilitates termination by maintaining levels of the poly(A) site endonuclease Ysh1. Cell Rep. 26: 1919-1935. Abstract

Whalen C, Tuohy C, Tallo T, Kaufman JW, Moore C, Kuehner JN. 2018. RNA polymerase II transcription attenuation at the yeast DNA repairgGene, DEF1, involves Sen1-dependent and polyadenylation site-dependent termination. G3 Epub ahead of print. Abstract

p>McGinty RJ, Puleo F, Aksenova AY, Hisey JA, Shishkin AA, Pearson EL, Wang ET, Housman DE, Moore C, Mirkin SM. 2017. A defective mRNA cleavage and polyadenylation complex facilitates expansions of transcribed (GAA)n repeats associated with Friedreich's Ataxia. Cell Rep. 20: 2490-2500.  Abstract

Kuehner JN, Kaufman JW, Moore C. 2017. Stimulation of RNA Polymerase II ubiquitination and degradation by yeast mRNA 3'-end processing factors is a conserved DNA damage response in eukaryotes. DNA Repair 57:151-160. Abstract

Yang F, Hsu P, Lee SD, Yang W, Xu W, Moore C, Varani G. 2017. The C-terminus of Pcf11 forms a novel zinc-finger structure that plays an essential role in mRNA 3'- end processing. RNA 23: 98-107.  Abstract

Costanzo M, Vander Sluis B, Koch E, Baryshnikova A, Pons C, Tan G, Wang W, Usaj M, Hanchard J, Lee SD, et al, Moore C, Caudy A, Myers C, Andrews B & Boone C. 2016 The global yeast genetic interaction network: a hierarchical model of cell function and conserved principles of inheritance. Science 353(6306).  Abstract

Blair L, Labitigan R, Liu Z, Zheng D, Pearson E, Nazeer F, Cao J, Rines R, Mackintosh S, Moore C, Li W, Tian B, Tackett A, Yan Q. 2016. KDM5 lysine demethylases are involved in maintenance of 3’ UTR length. Science Advances 2:e1501662. Abstract

Pearson E, Moore C. 2014. The evolutionarily conserved Pol II flap loop contributes to proper snoRNA transcription termination in yeast. Cell Reports 9:821-828. Abstract

Lee SD, Moore CL. 2014. Efficient mRNA polyadenylation requires a ubiquitin-like domain, a zinc knuckle, and a RING finger domain, all contained in the Mpe1 protein. Mol Cell Biol.34: 3955-3967. Abstract

Pearson EL, Moore CL. 2013. Dismantling promoter-driven RNA polymerase II transcription complexes in vitro by the termination factor Rat1. J Biol Chem. 288: 19750-19759. Abstract

Graber JH, Nazeer FI, Yeh PC, Kuehner JN, Borikar S, Hoskinson D, Moore CL. 2013. DNA damage induces targeted, genome-wide variation of poly(A) sites in budding yeast. Genome Res. 23: 1690-1703. Abstract

Barnwal RP, Lee SD, Moore C, Varani G. 2012. Structural and biochemical analysis of the assembly and function of the yeast pre-mRNA 3' end processing complex CF I. Proc Natl Acad Sci USA 109: 21342-21347. Abstract

Schmid M, Poulsen MB, Olszewski P, Pelechano V, Saguez C, Gupta I, Steinmetz LM, Moore C, Jensen TH. 2012. Rrp6p controls mRNA poly(A) tail length and its decoration with poly(A) binding proteins. Mol Cell 47: 267-280. Abstract

Ghazy MA, Gordon JM, Lee SD, Singh BN, Bohm A, Hampsey M, Moore C. 2012. The interaction of Pcf11 and Clp1 is needed for mRNA 3'-end formation and is modulated by amino acids in the ATP-binding site. Nucleic Acids Res. 40: 1214-1225. Abstract