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Graduate School of Biomedical Sciences

Recent Publications from the Kaplan Lab

Rodriguez M, Kluge JA, Smoot D, Kluge MA, Schmidt DF, Paetsch CR, Kim PS, Kaplan DL. 2019. Fabricating mechanically improved silk-based vascular grafts by solution control of the gel-spinning process. Biomaterials 23:119567. doi: 10.1016/j.biomaterials.2019.119567. Abstract

Parker RN, Wu WA, McKay TB, Xu Q, Kaplan DL. 2019. Design of silk-elastin-like protein nanoparticle systems with mucoadhesive properties. J Funct Biomater. 10(4). pii: E49. doi: 10.3390/jfb10040049. Abstract

Sood D, Tang-Schomer M, Pouli D, Mizzoni C, Raia N, Tai A, Arkun K, Wu J, Black LD 3rd, Scheffler B, Georgakoudi I, Steindler DA, Kaplan DL. 2019. 3D extracellular matrix microenvironment in bioengineered tissue models of primary pediatric and adult brain tumors. Nat Commun. 10(1):4529. doi: 10.1038/s41467-019-12420-1. Abstract

Simsa R, Yuen J, Stout A, Rubio N, Fogelstrand P, Kaplan DL. 2019. Extracellular heme proteins influence bovine myosatellite cell proliferation and the color of cell-based meat. Foods 8(10). pii: E521. doi: 10.3390/foods8100521. Abstract

Zhang Y, Raia N, Peterson A, Kaplan DL PhD, House MD. 2019. Injectable silk-based hydrogel as an alternative to cervical cerclage: a rabbit study. Tissue Eng Part A. Epub ahead of print. Abstract

Roh TT, Chen Y, Paul HT, Guo C, Kaplan DL. 2019. 3D bioengineered tissue model of the large intestine to study inflammatory bowel disease. Biomaterials 225: 119517. Abstract

McKay TB, Parker RN, Hawker MJ, McGill M, Kaplan DL. 2019. Silk-based therapeutics targeting Pseudomonas aeruginosa. J Funct Biomater. 10(3). pii: E41. doi: 10.3390/jfb10030041. Abstract

McKay TB, Ford A, Wang S, Cairns DM, Parker RN, Deardorff PM, Ghezzi CE, Kaplan DL. 2019. Assembly and application of a three-dimensional human corneal tissue model. Curr Protoc Toxicol. 81: e84. Abstract

Wang C, Xia K, Zhang Y, Kaplan DL. 2019. Silk-based advanced material for soft electronics. Acc Chem Res. Epub ahead of print. Abstract

Mooring M, Fowl BH, Lum SZC, Liu Y, Yao K, Softic S, Kirchner R, Bernstein A, Singhi AD, Jay DG, Kahn CR, Camargo FD, Yimlamai D. 2019. Hepatocyte stress increases expression of YAP and TAZ in hepatocytes to promote parenchymal inflammation and fibrosis. Hepatology doi: 10.1002/hep.30928. Abstract

Franco AR, Fernandes EM, Rodrigues MT, Rodrigues FJ, Gomes ME, Leonor IB, Kaplan DL, Reis RL. 2019. Acta Biomater. pii: S1742-7061(19)30616-6. doi: 10.1016/j.actbio.2019.09.004. Abstract

Mu X, Wang Y, Guo C, Li Y, Ling S, Huang W, Cebe P, Hsu HH, De Ferrari F, Jiang X, Xu Q, Balduini A, Omenetto FG, Kaplan DL. 2019. 3D printing of silk protein structures by aqueous solvent-directed molecular assembly. Macromol Biosci.21:e1900191. doi: 10.1002/mabi.201900191. Abstract

Izzy S, Liu Q, Fang Z, Lule S, Wu L, Chung JY, Sarro-Schwartz A, Brown-Whalen A, Perner C, Hickman SE, Kaplan DL, Patsopoulos NA, El Khoury J, Whalen MJ. 2019. Time-dependent changes in microglia transcriptional networks following traumatic brain injury. Front Cell Neurosci. 13: 307. Abstract

Vidal Yucha SE, Tamamoto KA, Kaplan DL. 2019. The importance of the neuro-immuno-cutaneous system on human skin equivalent design. Cell Prolif. e12677. doi: 10.1111/cpr.12677. Abstract

Choi J, McGill M, Raia NR, Hasturk O, Kaplan DL. 2019. Silk hydrogels crosslinked by the fenton reaction. Adv Healthc Mater. Epub ahead of print. Abstract

Manousiouthakis E, Chen Y, Cairns D, Pollard R, Gerlovin K, Dente M, Razavi Y, Kaplan DL. 2019. Bioengineered in vitro enteric nervous system. J Tissue Eng Regen Med. Epub ahead of print. Abstract

Belton DJ, Plowright R, Kaplan DL, Perry CC. 2019. A robust spectroscopic method for the determination of protein conformational composition - Application to the annealing of silk. Acta Biomater. 73: 355-364. Abstract

Yavuz B, Chambre L, Kaplan DL. 2019. Extended release formulations using silk proteins for controlled delivery of therapeutics.Expert Opin Drug Deliv. Epub ahead of print. Abstract

Gong H, Wang J, Zhang J, Wu J, Zheng Z, Xie X, Kaplan DL, Li G, Wang X. 2019. Control of octreotide release from silk fibroin microspheres. Mater Sci Eng C Mater Biol Appl. 102: 820-828. Abstract

Raia NR, Bakaysa SL, Ghezzi CE, House MD, Kaplan DL. 2019. Ex vivo pregnant-like tissue model to assess injectable hydrogel for preterm birth prevention. J Biomed Mater Res B Appl Biomater. Epub ahead of print. Abstract

Yavuz B, Zeki J, Taylor J, Harrington K, Coburn JM, Ikegaki N, Kaplan DL, Chiu B. 2019. Silk reservoirs for local delivery of cisplatin for neuroblastoma treatment: In vitro and in vivo evaluations. J Pharm Sci. Epub ahead of print. Abstract

Yavuz B, Morgan JL, Herrera C, Harrington K, Perez-Ramirez B, LiWang PJ, Kaplan DL. 2019. Sustained release silk fibroin discs: Antibody and protein delivery for HIV prevention. J Control Release. 301: 1-12. Abstract

Gupta AK, Coburn JM, Davis-Knowlton J, Kimmerling E, Kaplan DL, Oxburgh L. 2019. Scaffolding kidney organoids on silk. J Tissue Eng Regen Med. Epub ahead of print. Abstract

Setayeshmehr M, Esfandiari E, Rafienia M, Hashemibeni B, Taheri-Kafrani A, Samadikuchaksaraei A, Kaplan DL PhD, Moroni L, Joghataei M. 2019. Hybrid and composite scaffolds based on extracellular matrices for cartilage tissue engineering. Tissue Eng Part B Rev. Epub ahead of print. Abstract

Bradner SA, Galaiya D, Raol N, Kaplan DL, Hartnick CJ. 2019. Silk protein bioresorbable, drug-eluting ear tubes: Proof-of-concept. Adv Health Mater. Epub ahead of print. Abstract

Qiu Y, Poppleton E, Mekkat A, Yu H, Banerjee S, Wiley SE, Dixon JE, Kaplan DL, Lin YS, Brodsky B. 2018. Enzymatic phosphorylation of Ser in a type I collagen peptide. Biophys J Epub ahead of print. Abstract

Liaudanskaya V, Jgamadze D, Berk AN, Bischoff DJ, Gu BJ, Hawks-Mayer H, Whalen MJ, Chen HI, Kaplan DL. 2018. Engineering advanced neural tissue constructs to mitigate acute cerebral inflammation after brain transplantation in rats. Biomaterials 192: 510-522. Abstract

Deardorff PM, McKay TB, Wang S, Ghezzi CE, Cairns DM, Abbott RD, Funderburgh JL, Kenyon KR, Kaplan DL. 2018. Modeling diabetic corneal neuropathy in a 3D in vitro cornea system. Sci Rep. 8: 17294. Abstract

Hasturk O, Kaplan DL. 2018. Cell armor for protection against environmental stress: Advances, challenges and applications in micro- and nanoencapsulation of Mammalian Cells. Acta Biomater. Epub ahead of print. Abstract

McKay TB, Seyed-Razavi Y, Ghezzi CE, Dieckmann G, Nieland TJF, Cairns DM, Pollard RE, Hamrah P, Kaplan DL. 2018. Corneal pain and experimental model development. Prog Retin Eye Res. Epub ahead of print. Abstract

Yeo J, Huang W, Tarakanova A, Zhang YW, Kaplan DL, Buehler MJ. 2018. Unraveling the molecular mechanisms of thermo-responsive properties of silk-elastin-like proteins by integrating multiscale modeling and experiment. J Mater Chem B. 6: 3727-3734. Abstract

Roohaniesfahani I, Wang J, No YJ, de Candia C, Miao X, Lu Z, Shi J, Kaplan DL, Jiang X, Zreiqat H. 2019. Modulatory effect of simultaneously released magnesium, strontium, and silicon ions on injectable silk hydrogels for bone regeneration. Mater Sci Eng C Mater Biol Appl. 94: 976-987. Abstract

Roberts EG, Rim NG, Huang W, Tarakanova A, Yeo J, Buehler MJ, Kaplan DL, Wong JY. 2018. Fabrication and characterization of recombinant silk-elastin-like-protein (SELP) fiber. Macromol Biosci. Epub ahead of print. Abstract

Herrera-Rincon C, Golding AS, Moran KM, Harrison C, Martyniuk CJ, Guay JA, Zaltsman J, Carabello H, Kaplan DL, Levin M. 2018. Brief local application of progesterone via a wearable bioreactor induces long-term regenerative response in adult Xenopus hindlimb. Cell Rep. 25: 6: 1593-1609. Abstract

McGill M, Raol N, Gipson KS, Bowe SN, Fulk-Logan J, Nourmahnad A, Chung JY, Whalen MJ, Kaplan DL, Hartnick CJ 2018. Preclinical assessment of resorbable silk splints for the treatment of pediatric tracheomalacia. Laryngoscope Epub ahead of print. Abstract

Franco AR, Palma Kimmerling E, Silva C, Rodrigues FJ, Leonor IB, Reis RL, Kaplan DL. 2018. Silk-based antimicrobial polymers as a new platform to design drug-free materials to impede microbial infections. Macromol Biosci. 8: e1800262. Abstract

Cairns DM, Giordano JE, Conte S, Levin M, Kaplan DL. 2018. Ivermectin promotes peripheral nerve regeneration during wound healing. ACS Omega 3: 12392-12402. Abstract

Ling S, Jin K, Qin Z, Li C, Zheng K, Zhao Y, Wang Q, Kaplan DL, Buehler MJ. 2018. Combining in silico design and biomimetic assembly: A new approach for developing high-performance dynamic responsive bio-nanomaterials. Adv Mater. 23: 46. Abstract

Wang F, Wang Y, Tian C, Xu S, Wang R, Hou K, Chen W, Zhao P, Yu L, Lu Z, Kaplan DL, Xia Q. 2018. Fabrication of the FGF1-functionalized sericin hydrogels with cell proliferation activity for biomedical application using genetically engineered Bombyx mori (B. mori) silk. Acta Biomater. Epub ahead of print. Abstract

Martín-Moldes Z, Ebrahimi D, Plowright R, Dinjaski N, Perry CC, Buehler MJ, Kaplan DL. 2018. Intracellular pathways involved in bone regeneration triggered by recombinant silk-silica chimeras. Adv Funct Mater. 28 pii: 1702570. Abstract

Geryak R, Quigley E, Kim S, Korolovych VF, Calabrese R, Kaplan DL, Tsukruk VV. 2018. Tunable interfacial properties in silk ionomer microcapsules with tailored multilayer interactions. Macromol Biosci. Epub ahead of print. Abstract

Siran W, Ghezzi CE, Cairns DM, Pollard RE, Chen Y, Gomes R, McKay TB, Pouli D, Jamali A, Georgakoudi I, Funderburgh JL, Kenyon K, Hamrah P, Kaplan DL. 2018. Human corneal tissue model for nociceptive assessments. Adv Health Mater. Epub ahead of print. Abstract

Ding Y, Liu W, Yu W, Lu S, Liu M, Kaplan DL, Wang X. 2018. Three-dimensional tissue culture model of human breast cancer for the evaluation of multidrug resistance. J Tissue Eng Regen Med. Epub ahead of print. Abstract

Zeki J, Taylor JS, Yavuz B, Coburn J, Ikegaki N, Kaplan DL, Chiu B. 2018. Disseminated injection of vincristine-loaded silk gel improves the suppression of neuroblastoma tumor growth. Surgery Epub ahead of print. Abstract

McGill M, Holland GP, Kaplan DL. 2018. Experimental methods for characterizing the secondary structure and thermal properties of silk proteins. Macromol Rapid Commun. 2: e1800390. Abstract

Yavuz B, Zeki J, Coburn JM, Ikegaki N, Levitin D, Kaplan DL, Chiu B. 2018. In vitro and in vivo evaluation of etoposide - silk wafers for neuroblastoma treatment. J Control Release. 285: 162-171. Abstract

Wu L, Chung JY, Saith S, Tozzi L, Buckley EM, Sanders B, Franceschini MA, Lule S, Izzy S, Lok J, Edmiston WJ 3rd, McAllister LM, Mebane S, Jin G, Lu J, Sherwood JS, Willwerth S, Hickman S, Khoury JE, Lo EH, Kaplan D, Whalen MJ. 2018. Repetitive head injury in adolescent mice: A role for vascular inflammation. J Cereb Blood Flow Metab. Epub ahead of print. Abstract

Oktaviani NA, Matsugami A, Malay AD, Hayashi F, Kaplan DL, Numata K. 2018. Conformation and dynamics of soluble repetitive domain elucidates the initial β-sheet formation of spider silk. Nat Commun. 9: 2121.

House MD, Kelly J, Klebanov N, Yoshida K, Myers K, Kaplan DL PhD. 2018. Mechanical and biochemical effects of progesterone on engineered cervical tissue. Tissue Eng Part A Epub ahead of print. Abstract

Mekkat A, Poppleton E, An B, Visse R, Nagase H, Kaplan DL, Brodsky B, Lin YS. 2018. Effects of flexibility of the α2 chain of type I collagen on collagenase cleavage. J Struct Biol. Epub ahead of print. Abstract

Farokhi M, Mottaghitalab F, Fatahi Y, Khademhosseini A, Kaplan DL. 2018. Overview of silk fibroin use in wound dressings. Trends Biotechnol. Epub ahead of print. Abstract

Dinjaski N, Huang W, Kaplan DL. 2018. Recursive directional ligation approach for cloning recombinant spider silks. Methods Mol Biol. 1777: 181-192. Abstract

Vidal SEL, Tamamoto KA, Nguyen H, Abbott RD, Cairns DM, Kaplan DL. 2018. 3D biomaterial matrix to support long term, full thickness, immuno-competent human skin equivalents with nervous system components. Biomaterials Epub ahead of print. Abstract

Zhao S, Tseng P, Grasman J, Wang Y, Li W, Napier B, Yavuz B, Chen Y, Howell L, Rincon J, Omenetto FG, Kaplan DL. 2018. Programmable hydrogel ionic circuits for biologically matched electronic interfaces. Adv Mater. Epub ahead of print. Abstract

Brown JE, Tozzi L, Schilling B, Kelmendi-Doko A, Truong AB, Rodriguez MJ, Gil ES, Sucsy R, Valentin JE, Philips BJ, Marra KG, Rubin JP, Kaplan DL. 2018. Biodegradable silk catheters for the delivery of therapeutics across anatomical repair sites. J Biomed Mater Res B Appl Biomater Epub ahead of print. Abstract

Ashari N, Pang HW, Simon T, Xiong Y, Coburn JM, Bromberg JS, Kaplan DL, McLenithan J, Fontaine MJ. 2018. Silk fibroin preserves beta cell function under inflammatory stress while stimulating islet cell surface GLUT2 expression. Cell Immunol. Epub ahead of print. Abstract

Belton DJ, Plowright R, Kaplan DL, Perry CC.. 2018. A robust spectroscopic method for the determination of protein conformational composition- Application to the annealing of silk. Acta Biomater. Epub ahead of print. Abstract

Liu Z, Li G, Zheng Z, Li Y, Han Y, Kaplan DL, Wang X. 2018. Silk fibroin-based woven endovascular prosthesis with heparin surface modification. J Mater Sci Mater Med. 29:46. Abstract

Tseng P, Napier B, Garbarini L, Kaplan DL, Omenetto FG. 2018. Functional, RF-trilayer sensors for tooth-mounted, wireless monitoring of the oral cavity and food consumption. Adv Mater Epub ahead of print. Abstract

Jiang J, Zhang S, Qian Z, Qin N, Song W, Sun L, Zhou Z, Shi Z, Chen L, Li X, Mao Y, Kaplan DL, Gilbert Corder SN, Chen X, Liu M, Omenetto FG, Xia X, Tao TH. 2018. Protein bricks: 2D and 3D bio-nanostructures with shape and function on demand. Adv Mater. Epub ahead of print. Abstract

Rodriguez MJ, Dixon TA, Cohen E, Huang W, Omenetto FG, Kaplan DL. 2018. 3D freeform printing of silk fibroin. Acta Biomater. Epub ahead of print. Abstract

Tang-Schomer MD, Wu WB, Kaplan DL, Bookland MJ. 2018. In vitro 3D regeneration-like growth of human patient brain tissue. J Tissue Eng Regen Med. Epub ahead of print. Abstract

Montalbán MG, Coburn JM, Lozano-Pérez AA, Cenis JL, Víllora G, Kaplan DL. 2018. Production of curcumin-loaded silk fibroin nanoparticles for cancer therapy. Nanomaterials 8: 2.  Abstract

Shaban L, Chen Y, Fasciano AC, Lin Y, Kaplan DL, Kumamoto CA, Mecsas J. 2018. A 3D intestinal tissue model supports Clostridioides difficile germination, colonization, toxin production and epithelial damage. Anaerob 50: 85-92. Abstract

Xie X, Liu L, Zheng Z, Han Z, Zhi M, Kaplan DL, Li G, Wang X. 2018. Silk fibroin-based fibrous anal fistula plug with drug delivery function. Macromol Biosci. Epub ahead of print. Abstract

Cairns DM, Boorgu DSSK, Levin M, Kaplan DL. 2018. Niclosamide rescues microcephaly in a humanized in vivo model of Zika infection using human induced neural stem cells. Biol Open 7: pii: bio031807. doi: 10.1242/bio.031807.  Abstract

James E, Van Doren E, Li C, Kaplan DL 2018. Silk biomaterials-mediated miRNA functionalized orthopedic devices. Tissue Eng Part A. Epub ahead of print. Abstract

Zhou W, Chen Y, Roh T, Lin Y, Ling S, Zhao S, Lin JD, Khalil N, Cairns DM, Manousiouthakis E, Tse M, Kaplan DL. 2018. Multifunctional bioreactor system for human intestine tissues. ACS Biomater. Sci Eng. 4: 231-239. Abstract

Zheng Z, Wu J, Liu M, Wang H, Li C, Rodriguez MJ, Li G, Wang X, Kaplan DL. 2018. 3D bioprinting of self-standing silk-based bioink. Adv Healthc Mater. Epub ahead of print.  Abstract

Bhunia BK, Kaplan DL, Mandal BB. 2018. Silk-based multilayered angle-ply annulus fibrosus construct to recapitulate form and function of the intervertebral disc. Proc Natl Acad Sci USA 115: 477-482. Abstract

Sundarakrishnan A, Chen Y, Black LD, Aldridge BB, Kaplan DL. 2017. Engineered cell and tissue models of pulmonary fibrosis. Adv Drug Deliv Rev. Epub ahead of print. Abstract

Park YR, Sultan MT, Park HJ, Min Lee J, Ju HW, Lee OJ, Lee DJ, Kaplan DL, Park CH. 2018. NF-κB signaling is key in the wound healing processes of silk fibroin. Acta Biomater. 67: 183-195. Abstract