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Graduate School of Biomedical Sciences

Recent Publications from the Jaffe Lab

Gorini S, Kim SK, Infante M, Mammi C, La Vignera S, Fabbri A, Jaffe IZ, Caprio M. 2019. Role of aldosterone and mineralocorticoid receptor in cardiovascular aging. Front Endocrinol. 10:584. doi: 10.3389/fendo.2019.00584. Abstract

Lu Q, Davel AP, McGraw AP, Rao SP, Newfell BG, Jaffe IZ. 2019. PKC-delta mediates mineralocorticoid receptor activation by angiotensin II to modulate smooth muscle cell function. Endocrinology Epub ahead of print. Abstract

Faulkner JL, Kennard S, Huby AC, Antonova G, Lu Q, Jaffe IZ, Patel VS, Fulton DJR, Belin de Chantemèle EJ. 2019. Progesterone predisposes females to obesity-associated leptin-mediated endothelial dysfunction via upregulating endothelial MR (mineralocorticoid receptor) expression. Hypertension Epub ahead of print. Abstract

Moss ME, Lu Q, Iyer SL, Engelbertsen D, Marzolla V, Caprio M, Lichtman AH, Jaffe IZ. 2019. Endothelial mineralocorticoid receptors contribute to vascular inflammation in atherosclerosis in a sex-specific manner. Arterioscler Thromb Vasc Biol. 39: 1588-1601. Abstract

Zisa D, Hirst C, Chweich H, Conway L, Jaffe I, Kapur NK. 2019. Univentricular right heart support using a single axial flow catheter for high risk multivessel percutaneous coronary intervention. Cardiovasc Revasc Med. Epub ahead of print. Abstract

Moss ME, Carvajal B, Jaffe IZ. 2019. The endothelial mineralocorticoid receptor: Contributions to sex differences in cardiovascular disease. Pharmacol Ther. Epub ahead of print. Abstract

Aroor AR, Habibi J, Nistala R, Ramirez-Perez FI, Martinez-Lemus LA, Jaffe IZ, Sowers JR, Jia G, Whaley-Connell A. 2019. Diet-induced obesity promotes kidney endothelial stiffening and fibrosis dependent on the endothelial mineralocorticoid receptor. Hypertension 73: 849-858. Abstract

DuPont JJ, Kenney RM, Patel AR, Jaffe IZ. 2019. Sex differences in mechanisms of arterial stiffness. Br J Pharmacol. Epub ahead of print. Abstract

Biwer LA, Wallingford M, Jaffe IZ. 2018. Vascular Mineralocorticoid Receptor: Evolutionary mediator of wound healing turned harmful by our modern lifestyle. Am J Hypertens. 32: 123-134. Abstract

Moss ME, DuPont JJ, Iyer SL, McGraw AP, Jaffe IZ. 2018. No significant role for smooth muscle cell mineralocorticoid receptors in atherosclerosis in the apolipoprotein-E knockout mouse model. Front Cardiovasc Med. 5:81. Abstract

Esposito ML, Zhang Y, Qiao X, Reyelt L, Paruchuri V, Schnitzler GR, Morine KJ, Annamalai SK, Bogins C, Natov PS, Pedicini R, Breton C, Mullin A, Mackey EE, Patel A, Rowin E, Jaffe IZ, Karas RH, Kapur NK. 2018. Left ventricular unloading before reperfusion promotes functional recovery after acute myocardial infarction. J Am Coll Cardiol. 72: 501-514. Abstract

Gopal S, Lu Q, Man JJ, Baur W, Rao SP, Litichevskiy L, Papanastasiou M, Creech AL, DeRuff KC, Mullahoo J, Officer A, Egri SB, Davison D, Jaffe JD, Jaffe IZ. 2018. A phosphoproteomic signature in endothelial cells predicts vascular toxicity of tyrosine kinase inhibitors used in CML. Blood Adv. 2: 1680-1684. Abstract

Davel AP, Jaffe IZ, Tostes RC, Jaisser F, Belin de Chantemèle EJ. 2018. New Roles of aldosterone and mineralocorticoid receptors in cardiovascular disease: Translational and sex-specific effects. Am J Physiol Heart Circ Physiol. 315: H989-H999. Abstract

Davel AP, Lu Q, Moss ME, Rao S, Anwar IJ, DuPont JJ, Jaffe IZ. 2018. J Am Heart Assoc 7: pii: e007675. doi: 10.1161/JAHA.117.007675. Abstract

Kim SK, McCurley AT, DuPont JJ, Aronovitz M, Moss ME, Stillman IE, Karumanchi SA, Christou DD, Jaffe IZ. 2018. Smooth muscle cell-mineralocorticoid receptor as a mediator of cardiovascular stiffness with aging. Hypertension 71: 609-621. Abstract

Diaz-Otero JM, Fisher C, Downs K, Moss ME, Jaffe IZ, Jackson WF, Dorrance AM. 2017. Endothelial mineralocorticoid receptor mediates parenchymal arteriole and posterior cerebral artery remodeling during angiotensin II-induced hypertension. Hypertension 70: 1113-1121.  Abstract

Salvador AM, Moss ME, Aronovitz M, Mueller KB, Blanton RM, Jaffe IZ, Alcaide P. 2017. Endothelial mineralocorticoid receptor contributes to systolic dysfunction induced by pressure overload without modulating cardiac hypertrophy or inflammation. Physiol Rep. 5 (12).  Abstract

Marzolla V, Armani A, Mammi C, Moss ME, Pagliarini V, Pontecorvo L, Antelmi A, Fabbri A, Rosano G, Jaffe IZ, Caprio M. 2017. Essential role of ICAM-1 in aldosterone-induced atherosclerosis. Int J Cardiol. 232: 233-242.  Abstract

Davel AP, Anwar IJ, Jaffe IZ. 2017. The endothelial mineralocorticoid receptor: mediator of the switch from vascular health to disease. Curr Opin Nephrol Hypertens. 26: 97-104.  Abstract

Lu Q, Schnitzler GR, Vallaster CS, Ueda K, Erdkamp S, Briggs CE, Iyer LK, Jaffe IZ, Karas RH. 2017. Unliganded estrogen receptor alpha regulates vascular cell function and gene expression. Mol Cell Endocrinol. 442: 12-23.  Abstract

DuPont JJ, McCurley A, Davel AP, McCarthy J, Bender SB, Hong K, Yang Y, Yoo JK, Aronovitz M, Baur WE, Christou DD, Hill MA, Jaffe IZ. 2016. Vascular mineralocorticoid receptor regulates microRNA-155 to promote vasoconstriction and rising blood pressure with aging. JCI Ingsiht 1: e88942.  Abstract

Gopal S, Miller KB, Jaffe IZ. 2016. Molecular mechanisms for vascular complications of targeted cancer therapies. Clin Sci. 130: 1763-1779. Abstract

Victorio JA, Clerici SP, Palacios R, Alonso MJ, Vassallo DV, Jaffe IZ, Rossoni LV, Davel AP. 2016. Spironolactone prevents endothelial nitric oxide synthase uncoupling and vascular dysfunction induced by β-adrenergic overstimulation: Role of perivascular adipose tissue. Hypertension 68: 726-735 .  Abstract

Burke SD, Zsengellér ZK, Khankin EV, Lo AS, Rajakumar A, DuPont JJ, McCurley A, Moss ME, Zhang D, Clark CD, Wang A, Seely EW, Kang PM, Stillman IE, Jaffe IZ, Karumanchi SA. 2016. Soluble fms-like tyrosine kinase 1 promotes angiotensin II sensitivity in preeclampsia. J Clin Invest. 126: 2561-2574. Abstract

Salvador AM, Nevers T, Velázquez F, Aronovitz M, Wang B, Abadía Molina A, Jaffe IZ, Karas RH, Blanton RM, Alcaide P. 2016. Intercellular adhesion molecule 1 regulates left ventricular leukocyte infiltration, cardiac remodeling, and function in pressure overload-induced heart failure. J Am Heart Assoc. pii: e003126.  Abstract

Jia G, Habibi J, Aroor AR, Martinez-Lemus LA, DeMarco VG, Ramirez-Perez FI, Sun Z, Hayden MR, Meininger GA, Barrett Mueller KV, Jaffe IZ, Sowers JR. 2016. Endothelial mineralocorticoid receptor mediates diet induced aortic stiffness in females. Circ Res. 118: 935-943. Abstract

Morine KJ, Paruchuri V, Qiao X, Mohammad N, Mcgraw A, Yunis A, Jaffe I, Kapur NK. 2015. Circulating multimarker profile of patients with symptomatic heart failure supports enhanced fibrotic degradation and decreased angiogenesis. Biomarkers 15: 1-7. Abstract

Hwang MH, Yoo JK, Luttrell M, Kim HK, Meade TH, English M, Talcott S, Jaffe IZ, Christou DD 2015. Acute effect of mineralocorticoid receptor antagonism on vascular function in healthy older adults. Exp Gerontol. 73: 86-94. Abstract

Jia G, Habibi J, DeMarco VG, Martinez-Lemus LA, Ma L, Whaley-Connell AT, Aroor AR, Domeier TL, Zhu Y, Meininger GA, Mueller KB, Jaffe IZ, Sowers JR. 2015. Endothelial mineralocorticoid receptor deletion prevents diet-induced cardiac diastolic dysfunction in females. Hypertension 66: 1159-1167. Abstract

Moss ME, Jaffe IZ. 2015. Mineralocorticoid receptors in the pathophysiology of vascular inflammation and atherosclerosis. Front Endocrinol (Lausanne) 6: 153. Abstract

Amador CA, Bertocchio JP, Andre-Gregoire G, Placier S, Duong Van Huyen JP, El Moghrabi S, Berger S, Warnock DG, Chatziantoniou C, Jaffe IZ, Rieu P, Jaisser F. 2015. Deletion of mineralocorticoid receptors in smooth muscle cells blunts renal vascular resistance following acute cyclosporine administration. Kidney Int. Epub ahead of print.  Abstract

Mueller KB, Bender SB, Hong K, Yang Y, Aronovitz M, Jaisser F, Hill MA, Jaffe IZ. 2015. Endothelial mineralocorticoid receptors differentially contribute to coronary and mesenteric vascular function without modulating blood pressure. Hypertension 66: 988-997.  Abstract

Pruthi D, Khankin EV, Blanton RM, Aronovitz M, Burke SD, McCurley A, Karumanchi SA, Jaffe IZ. 2015. Exposure to experimental preeclampsia in mice enhances the vascular response to future injury. Hypertension 65: 863-870. Abstract

Bender SB, DeMarco VG, Padilla J, Jenkins NT, Habibi J, Garro M, Pulakat L, Aroor AR, Jaffe IZ, Sowers JR. 2015. Mineralocorticoid receptor antagonism treats obesity-associated cardiac diastolic dysfunction. Hypertension 65: 1082-1088. Abstract

Pruthi D, Khankin EV, Blanton RM, Aronovitz M, Burke SD, McCurley A, Karumanchi SA, Jaffe IZ. 2015. Exposure to experimental preeclampsia in mice enhances the vascular response to future injury. Hypertension 65: 863-870. Abstract