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Graduate School of Biomedical Sciences

Recent Publications from the G Hu Lab

Yu W, Goncalves KA, Li S, Kishikawa H, Sun G, Yang H, Vanli N, Wu Y, Jiang Y, Hu MG, Friedel RH, Hu GF. 2017. Plexin-B2 mediates physiologic and pathologic functions of angiogenin. Cell 171: 849-864. Abstract

Goncalves KA, Silberstein L, Li S, Severe N, Hu MG, Yang H, Scadden DT, Hu GF. 2016. Angiogenin promotes hematopoietic regeneration by dichotomously regulating quiescence of stem and progenitor cells. Cell 166: 894-906. Abstract

Silberstein L, Goncalves KA, Kharchenko PV, Turcotte R, Kfoury Y, Mercier F, Baryawno N, Severe N, Bachand J, Spencer JA, Papazian A, Lee D, Chitteti BR, Srour EF, Hoggatt J, Tate T, Lo Celso C, Ono N, Nutt S, Heino J, Sipilä K, Shioda T, Osawa M, Lin CP, Hu GF, Scadden DT. 2016. Cell Stem Cell Epub ahead of print. Abstract

Jena N, Sheng J, Hu JK, Li W, Zhou W, Lee G, Tsichlis N, Pathak A, Brown N, Deshpande A, Luo C, Hu GF, Hinds PW, Van Etten RA, Hu MG. 2016. CDK6-mediated repression of CD25 is required for induction and maintenance of Notch1-induced T cell acute lymphoblastic leukemia. Leukemia Epub ahead of print. Abstract

Vanli N, Guo-Fu Hu. 2015. Mechanism and function of angiogenin in prostate cancer. Zhongguo Sheng Wu Hua Xue Yu Fen Zi Sheng Wu Xue Bao. 31: 1261-1266. Abstract

Goncalves KA, Hu GF. 2015. Mechanism and function of angiogenin in hematopoietic malignancy. Zhongguo Sheng Wu Hua Xue Yu Fen Zi Sheng Wu Xue Bao 31: 1267-1275. Abstract

Saikia M, Jobava R, Parisien M, Putnam A, Krokowski D, Gao XH, Guan BJ, Yuan Y, Jankowsky E, Feng Z, Hu GF, Pusztai-Carey M, Gorla M, Sepuri NB, Pan T, Hatzoglou M 2014. Angiogenin-cleaved tRNA halves interact with cytochrome c, protecting cells from apoptosis during osmotic stress. Mol Cell Biol. 34: 2450-2463. Abstract

Sheng J, Luo C, Jiang Y, Hinds PW, Xu Z, Hu GF. 2014. Transcription of angiogenin and ribonuclease 4 is regulated by RNA Polymerase III elements and a CCCTC-binding factor (CTCF)-dependent intragenic chromatin loop. J Biol Chem. 289: 12520-12534. Abstract

Sheng J, Yu W, Gao X, Xu Z, Hu GF. 2014. Angiogenin stimulates ribosomal RNA transcription by epigenetic activation of the ribosomal DNA promoter. J Cell Physiol. 229: 521-529. Abstract

Li S, Hu MG, Sun Y, Yoshioka N, Ibaragi S, Sheng J, Sun G, Kishimoto K, Hu GF. 2013. Angiogenin mediates androgen-stimulated growth of prostate cancer cells and correlates with castration resistance. Mol Cancer Res. 11: 1203-1214. Abstract

Pizzo E, Sarcinelli C, Sheng J, Fusco S, Formiggini F, Netti P, Yu W, D'Alessio G, Hu GF. 2013. Ribonuclease/angiogenin inhibitor 1 regulates stress-induced subcellular localization of angiogenin and controls its growth and survival activities. J Cell Sci. 126: 4308-4319.Abstract

Luo C, Sheng J, Hu MG, Haluska FG, Cui R, Xu Z, Tsichlis PN, Hu GF, Hinds PW. 2013. Loss of ARF sensitizes transgenic BRAFV600E mice to UV-induced melanoma via suppression of XPC. Cancer Res. 73: 4337-4348. Abstract

Li S, Sheng J, Hu JK, Yu W, Kishikawa H, Hu MG, Shima K, Wu D, Xu Z, Xin W, Sims KB, Landers JE, Brown RH Jr, Hu GF. 2012. Ribonuclease 4 protects neuron degeneration by promoting angiogenesis, neurogenesis, and neuronal survival under stress. Angiogenesis 16: 387-404. Abstract

Saikia M, Krokowski D, Guan BJ, Ivanov P, Parisien M, Hu GF, Anderson P, Pan T, Hatzoglou M. 2012. Genome-wide identification and quantitative analysis of cleaved tRNA fragments induced by cellular stress. J Biol Chem. 287: 42708-42725. Abstract

Kishimoto K, Yoshida S, Ibaragi S, Yoshioka N, Okui T, Hu GF, Sasaki A. 2012. Hypoxia-induced up-regulation of angiogenin, besides VEGF, is related to progression of oral cancer. Oral Oncol. 48: 1120-1127. Abstract

Li S, Hu GF.  2012. Emerging role of angiogenin in stress response and cell survival under adverse conditions. J Cell Physiol. 227: 2822-2826. Abstract

Li S, Yu W, Hu GF. 2012. Angiogenin inhibits nuclear translocation of apoptosis inducing factor in a Bcl-2-dependent manner. J Cell Physiol. 227: 1639-1644. Abstract