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Graduate School of Biomedical Sciences

Recent Publications from the Heldwein Lab

White EM, Stampfer SD, Heldwein EE. 2019. Expression, purification, and crystallization of HSV-1 glycoproteins for structure determination. Methods Mol Biol. 2020;2060:377-393. doi: 10.1007/978-1-4939-9814-2_23. Abstract

Cooper RS, Heldwein EE. 2019. Expression, purification, and crystallization of full-length HSV-1 gB for structure determination. Methods Mol Biol. 2020;2060:395-407. doi: 10.1007/978-1-4939-9814-2_24. Abstract

Hilterbrand AT, Heldwein EE. 2019. Go go gadget glycoprotein!: HSV-1 draws on its sizeable glycoprotein tool kit to customize its diverse entry routes. PLoS Pathog. 15: e1007660. Abstract

Koenigsberg AL, Heldwein E. 2018. The dynamic nature of the conserved tegument protein UL37 of herpesviruses. J Biol Chem. Epub ahead of print. Abstract

Cooper RS, Georgieva ER, Borbat PP, Freed JH, Heldwein EE. 2018. Structural basis for membrane anchoring and fusion regulation of the herpes simplex virus fusogen gB. Nat Struct Mol Biol. 25: 416-424. Abstract

Heldwein EE. 2018. Up close with herpesviruses. Science 360: 34-35. Abstract

Richards AL, Sollars PJ, Pitts JD, Stults AM, Heldwein EE, Pickard GE, Smith GA. 2017. The pUL37 tegument protein guides alpha-herpesvirus retrograde axonal transport to promote neuroinvasion. PLoS Pathog. 13: e1006741. Abstract

Koenigsberg AL, Heldwein EE. 2017. Crystal structure of the N-terminal half of the traffic controller UL37 from Herpes Simplex virus Type 1. J Virol. 91: e01244-17 . Abstract

Wang P, Yu Z, Santangelo TJ, Olesik J, Wang Y, Heldwein E, Li X. 2017. BosR is a novel Fur family member responsive to copper and regulating copper homeostasis in Borrelia burgdorferi. J Bacteriol. Epub ahead of print. Abstract

Bigalke JM, Heldwein EE. 2017. Have NEC coat, will travel: Structural basis of membrane budding during nuclear egress in herpesviruses. Adv Virus Res. 97:107-141. Abstract

Rogalin HB, Heldwein EE. 2016. Characterization of VSV pseudotypes bearing essential entry glycoproteins gB, gD, gH, and gL of Herpes Simplex virus Type 1. J Virol. Epub ahead of print. Abstract

Biglake JM, Heldwein EE. 2016. Expression, purification and crystallization of the herpesvirus nuclear egress complex (NEC). Bio Protoc 6: e1872. Abstract

Bigalke JM, Heldwein EE. 2016. Nuclear exodus: Herpesviruses lead the way. Annu Rev Virol. 3: 387-409 . Abstract

Metrick CM, Heldwein EE. 2016. The novel structure and unexpected RNA-binding ability of the C-terminal domain of HSV-1 tegument protein UL21. J Virol. 90: 5759-69.  Erratum: J Virol. 90: 7007-7008. Abstract

Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Christopher Fromme J, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P. 2016. Data publication with the structural biology data grid supports live analysis. Nat Commun. 7: 10882.  Abstract

Heldwein EE. 2016. gH/gL supercomplexes at early stages of herpesvirus entry. Curr Opin Virol. 18: 1-8. Abstract

Cooper RS, Heldwein EE. 2015. Herpesvirus gB: A finely tuned fusion machine. Viruses 7: 6552-6569.  Abstract

Bigalke JM, Heldwein EE. 2015. Structural basis of membrane budding by the nuclear egress complex of herpesviruses. EMBO J. 34: 2921-2936.  Abstract

Burke HG, Heldwein EE 2015. Crystal structure of the human cytomegalovirus glycoprotein B. PLoS Pathog. 11: e1005227.  Abstract

Rogalin HB, Heldwein EE. 2015. The interplay between the HSV-1 gB cytodomains and the gH cytotail during cell-cell fusion. J Virol. 89: 12262-12272. Abstract

Bigalke JM, Heldwein EE. 2015. The great (nuclear) escape: new insights into the role of the nuclear egress complex of herpesviruses. J Virol. 89: 9150-9153. Abstract

Metrick CM, Chadha P, Heldwein EE. 2014. The unusual fold of HSV-1 UL21, a multifunctional tegument protein. J Virol. 89: 2979-2984. Abstract

Bigalke JM, Heuser T, Nicastro D, Heldwein EE. 2014. Membrane deformation and scission by the HSV-1 nuclear egress complex. Nat Commun. 5: 4131. Abstract

Stampfer SD, Heldwein EE. Expression, purification, and crystallization of HSV-1 glycoproteins for dtructure determination. Methods Mol Biol. 1144: 249-263. Abstract

Pitts JD, Klabis J, Richards AL, Smith GA, Heldwein EE. 2014. Crystal structure of the herpesvirus inner tegument protein UL37 supports its essential role in control of viral trafficking. J Virol. 88: 5462-5473. Abstract

Silverman JL, Heldwein EE. 2013. Mutations in the cytoplasmic tail of HSV-1 gH reduce the fusogenicity of gB in transfected cells. J Virol. 87: 10139-10147. Abstract

Vitu E, Sharma S, Stampfer SD, Heldwein EE. 2013. Extensive mutagenesis of the HSV-1 gB ectodomain reveals remarkable stability of its postfusion form. J Mol Biol. 425: 2056-2071. Abstract

Sharma S, Wisner TW, Johnson DC, Heldwein EE. 2013. HCMV gB shares structural and functional properties with gB proteins from other herpesviruses. Virology 435: 239-249. Abstract

Stampfer SD, Heldwein EE. 2013. Stuck in the middle: structural insights into the role of the gH/gL heterodimer in herpesvirus entry. Curr Opin Virol. 3: 13-19. Abstract