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Graduate School of Biomedical Sciences

Recent Publications from the Feig Lab

Dickson DA, Paulus JK, Mensah V, Lem J, Saavedra-Rodriguez L, Gentry A, Pagidas K, Feig LA. 2018. Reduced levels of miRNAs 449 and 34 in sperm of mice and men exposed to early life stress. Transl Psychiatry 8: 101. Abstract

Wong R, Feig LA. 2016. Tyrosine phosphorylation of RalGDS by c-Met receptor blocks its interaction with Ras. Biochem Biophys Res Commun. Epub ahead of print.  Abstract

Uzturk BG, Jin SX, Rubin B, Bartolome C, Feig LA. 2015. Ras-GRF1 regulates the HPA axis specifically in early-adolescent female mice. J Endocrinol. 227: 1-12.  Abstract

Darcy MJ, Jin SX, Feig LA. 2014. R-Ras contributes to LTP and contextual discrimination. Neuroscience 277: 334-342. Abstract

Darcy MJ, Trouche S, Jin SX, Feig LA. 2014. Ras-GRF2 mediates LTP, survival and response to an enriched environment of newborn neurons in the hippocampus. Hippocampus 24: 1317-1329. Abstract

Jin SX, Bartolome C, Arai JA, Hoffman L, Uzturk BG, Kumar-Singh R, Waxham MN, Feig LA. 2014. Domain contributions to signaling specificity differences between Ras-Guanine Nucleotide Releasing Factor (Ras-GRF)1 and Ras-GRF2. J Biol Chem. 289: 16551-16664. Abstract

Darcy MJ, Trouche S, Jin SX, Feig LA. 2013. Age-dependent role for ras-GRF1 in the late stages of adult neurogenesis in the dentate gyrus. Hippocampus 24: 315-325. Abstract

Jin SX, Arai J, Tian X, Kumar-Singh R, Feig LA. 2013. Acquisition of contextual discrimination involves the appearance of a Ras-GRF1/p38 map kinase-mediated signaling pathway that promotes LTP. J Biol Chem. 288: 21703-21713. Abstract

Saavedra-Rodríguez L, Feig LA. 2013. Chronic social instability induces anxiety and defective social interactions across generations. Biol Psychiatry 73: 44-53. Abstract

Feig, LA. 2011. Regulation of neuronal function by Ras-GRF exchange factors. Genes Cancer 2: 306-319. Abstract

Alt-Holland A, Sowalsky AG, Szwec-Levin Y, Shamis Y, Hatch H, Feig LA, Garlick JA. 2011. Suppression of E-cadherin function drives the early stages of Ras-induced squamous cell carcinoma through upregulation of FAK and Src. J Invest Dermatol. 131: 2306-2315. Abstract

Sowalsky AG, Alt-Holland A, Shamis Y, Garlick JA, Feig LA. 2011. RalA function in dermal fibroblasts is required for the progression of squamous cell carcinoma of the skin. Cancer Res. 71: 758-767.  Abstract

Arai JA, Feig LA. 2011. Long-lasting and transgenerational effects of an environmental enrichment on memory formation. Brain Res Bull. 85: 30-35. Abstract