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Graduate School of Biomedical Sciences

Recent Publications from the Chishti Lab

Mills J, Hanada T, Hase Y, Liscum L, Chishti AH. 2019. LDL receptor related protein 1 requires the I3 domain of discs-large homolog 1/DLG1 for interaction with the kinesin motor protein KIF13B. Biochim Biophys Acta Mol Cell Res. 2:118552. doi: 10.1016/j.bbamcr.2019.118552. Abstract

Schwake C, Baldwin MR, Bachovchin W, Hegde S, Schiemer J, Okure C, Levin AE, Vannier E, Hanada T, Chishti AH. 2019. HIV protease inhibitors block parasite signal peptide peptidases and prevent growth of Babesia microti parasites in erythrocytes. Biochem Biophys Res Commun. Epub ahead of print. Abstract

Almukadi H, Schwake C, Kaiser M, Mayer G, Schiemer J, Baldwin M, Hegde S, Lu Y, Hanada T, Chishti AH. 2019. Human erythrocyte band 3 is a host receptor for Plasmodium falciparum glutamic acid-rich protein. Blood 133: 470-480. Abstract

Fritz DI, Hanada T, Lu Y, Johnston JM, Chishti AH. 2019. MPP1/p55 gene deletion in a hemophilia A patient with ectrodactyly and severe developmental defects. Am J Hematol. 94: E29-E32. Abstract

Nwankwo JO, Gremmel T, Gerrits AJ, Mithila FJ, Warburton RR, Hill NS, Lu Y, Richey LJ, Jakubowski JA, Frelinger AL 3rd, Chishti AH. 2017. Calpain-1 regulates platelet function in a humanized mouse model of sickle cell disease. Thromb Res. 160: 58-65.  Abstract

Schiemer J, Bohm A, Lin L, Merrill-Skoloff G, Flaumenhaft R, Huang JS, Le Breton GC, Chishti AH. 2016. Gα13 switch region 2 relieves talin autoinhibition to activate IαIbβ3 integrin. J Biol Chem. 291: 26598-26612.  Abstract

Ranjan R, Karpurapu M, Rani A, Chishti AH, Christman JW. 2016. Hemozoin regulates iNOS expression by modulating the transcription factor NF-κB in macrophages. Biochem Mol Biol J. 2: pii: 10.  Abstract

Nwankwo JO, Lei J, Xu J, Rivera A, Gupta K, Chishti AH. 2016. Genetic inactivation of calpain-1 attenuates pain sensitivity in a humanized mouse model of sickle cell disease. Haematologica 101: e397-e400.  Abstract

Lu Y, Hanada T, Fujiwara Y, Nwankwo JO, Wieschhaus AJ, Hartwig J, Huang S, Han J, Chishti AH. 2016. Gene disruption of dematin causes precipitous loss of erythrocyte membrane stability and severe hemolytic anemia. Blood 128: 93-103.  Abstract

Howatt DA, Balakrishnan A, Moorleghen JJ, Muniappan L, Rateri DL, Uchida HA, Takano J, Saido TC, Chishti AH, Baud L, Subramanian V. 2016. Leukocyte calpain deficiency reduces angiotensin II-induced inflammation and atherosclerosis but not abdominal aortic aneurysms in mice. Arterioscler Thromb Vasc Biol. 36: 835-845.  Abstract

Srinivasan S, Schiemer J, Zhang X, Chishti AH, Le Breton GC. 2015. Gα13 switch region 2 binds to the talin head domain and activates αIIbβ3 integrin in human platelets. J Biol Chem. 290: 25129-25139.  Abstract

Baldwin MR, Li X, Hanada T, Liu SC, Chishti AH. 2015. Merozoite surface protein 1 recognition of host glycophorin A mediates malaria parasite invasion of red blood cells. Blood 125: 2704-2711.  Abstract

Chishti AH. 2015. Malaria selectively targets pregnancy receptors. Blood 125: 217-218. Abstract

Baldwin M, Yamodo I, Ranjan R, Li X, Mines G, Marinkovic M, Hanada T, Oh SS, Chishti AH. 2014. Human erythrocyte Band 3 functions as a receptor for the sialic acid-independent invasion of Plasmodium falciparum. Role of the RhopH3-MSP1 complex. Biochim Biophys Acta 1843: 2855-2870. Abstract

Baldwin M, Russo C, Li X, Chishti AH. 2014. Plasmodium falciparum signal peptide peptidase cleaves malaria heat shock protein 101 (HSP101). Implications for gametocytogenesis. Biochem Biophys Res Commun. 450: 1427-1432. Abstract

Wang Y, Briz V, Chishti A, Bi X, Baudry M. 2013. Distinct roles for μ-calpain and m-calpain in synaptic NMDAR-mediated neuroprotection and extrasynaptic NMDAR-mediated neurodegeneration. J Neurosci. 33: 18880-18892. Abstract

Subramanian V, Moorleghen JJ, Balakrishnan A, Howatt DA, Chishti AH, Uchida HA. 2013. Calpain-2 compensation promotes angiotensin II-induced ascending and abdominal aortic aneurysms in calpain-1 deficient mice. PLoS One 8: e72214. Abstract

Mattheij NJ, Gilio K, van Kruchten R, Jobe SM, Wieschhaus AJ, Chishti AH, Collins P, Heemskerk JW, Cosemans JM. 2013. Dual mechanism of integrin αIIbβ3 closure in procoagulant platelets. J Biol Chem. 288: 13325-13336. Abstract

De Franceschi L, Franco RS, Bertoldi M, Brugnara C, Matté A, Siciliano A, Wieschhaus AJ, Chishti AH, Joiner CH. 2013. Pharmacological inhibition of calpain-1 prevents red cell dehydration and reduces Gardos channel activity in a mouse model of sickle cell disease. FASEB J. 27: 750-759. Abstract

Wieschhaus AJ, Le Breton GC, Chishti AH. 2012. Headpiece domain of dematin regulates calcium mobilization and signaling in platelets. J Biol Chem. 287: 41218-41231. Abstract

Wieschhaus A, Khan A, Zaidi A, Rogalin H, Hanada T, Liu F, De Franceschi L, Brugnara C, Rivera A, Chishti AH. 2012. Calpain-1 knockout reveals broad effects on erythrocyte deformability and physiology. Biochem J. 448:141-152. Abstract

Yamada KH, Kozlowski DA, Seidl SE, Lance S, Wieschhaus AJ, Sundivakkam P, Tiruppathi C, Chishti I, Herman IM, Kuchay SM, Chishti AH. 2012. Targeted gene inactivation of calpain-1 suppresses cortical degeneration due to traumatic brain injury and neuronal apoptosis induced by oxidative stress. J Biol Chem. 287: 13182-13193. Abstract

Li X, Marinkovic M, Russo C, McKnight CJ, Coetzer TL, Chishti AH. 2012. Identification of a specific region of Plasmodium falciparum EBL-1 that binds to host receptor glycophorin B and inhibits merozoite invasion in human red blood cells. Mol Biochem Parasitol. 183: 23-31. Abstract