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Graduate School of Biomedical Sciences

Recent Publications from the J Chen Lab

Wu X, Qiu W, Hu Z, Lian J, Liu Y, Zhu X, Tu M, Fang F, Yu Y, Valverde P, Tu Q, Yu Y, Chen J. 2019. An adiponectin receptor agonist reduces type 2 diabetic periodontitis. J Dent Res. Epub ahead of print. Abstract

Jiang H, Wu Y, Valverde P, Murray D, Tang J, Yao Q, Han Q, Zhang J, Zhang L, Sui L, Tang Y, Tu Q, Chen J. 2018. Central adiponectin induces trabecular bone mass partly through epigenetic downregulation of cannabinoid receptor CB1. J Cell Physiol. Epub ahead of print. Abstract

Sui L, Wang M, Han Q, Yu L, Zhang L, Zheng L, Lian J, Zhang J, Valverde P, Xu Q, Tu Q, Chen J. 2018. A novel Lipidoid-MicroRNA formulation promotes calvarial bone regeneration. Biomaterials 177: 88-97. Abstract

Tang Y, Zhang L, Tu T, Li Y, Murray D, Tu Q, Chen JJ. 2018. MicroRNA-99a is a novel regulator of KDM6B-mediated osteogenic differentiation of BMSCs. J Cell Mol Med. Epub ahead of print. Abstract

Zhang L, Tang Y, Zhu X, Tu T, Sui L, Han Q, Yu L, Meng S, Zheng L, Valverde P, Tang J, Murray D, Zhou X, Drissi H, Dard MM, Tu Q, Chen J. Overexpression of MiR-335-5p Promotes Bone Formation and Regeneration in Mice. J Bone Miner Res. Epub ahead of print. Abstract

Zhang J, Valverde P, Zhu X, Murray D, Wu Y, Yu L, Jiang H, Dard MM, Huang J, Xu Z, Tu Q, Chen J. 2017. Exercise-induced irisin in bone and systemic irisin administration reveal new regulatory mechanisms of bone metabolism. Bone Res. 5: 16056. Abstract

Zhang J, Chen J. 2017. Bone tissue regeneration - Application of mesenchymal stem cells and cellular and molecular mechanisms. Curr Stem Cell Res Ther. 12: 357-364. Abstract

Zheng L, Tu Q, Meng S, Zhang L, Yu L, Song J, Hu Y, Sui L, Zhang J, Dard M, Cheng J, Murray D, Lian J, Stein G, Chen J. 2017. Runx2/DICER/miRNA pathway in regulating osteogenesis. J Cell Physiol. 232: 182-191. Abstract

Xuan D, Han Q, Tu Q, Zhang L, Yu L, Murry D, Tu T, Tang Y, Lian JB, Stein GS, Valverde P, Zhang J, Chen J. 2016. Epigenetic modulation in periodontitis: Interaction of adiponectin and JMJD3-IRF4 axis in macrophages. J Cell Physiol. 231: 1090-1096. Abstract

Han Q, Yang P, Wu Y, Meng S, Sui L, Zhang L, Yu L, Tang Y, Jiang H, Xuan D, Kaplan DL PhD, Kim SH, Tu Q, Chen J. 2015. Epigenetically modified bone marrow stromal cells (BMSCs) in silk scaffolds promote craniofacial bone repair and wound healing. Tissue Eng Part A 21: 2156-2165. Abstract

Yu L, Tu Q, Han Q, Zhang L, Sui L, Zheng L, Meng S, Tang Y, Xuan D, Zhang J, Murray D, Shen Q, Cheng J, Kim SH, Dong LQ, Valverde P, Cao X, Chen J. 2015. Adiponectin regulates bone marrow mesenchymal stem cell niche through a unique signal transduction pathway - an approach for treating bone disease in diabetes. Stem Cells 33: 240-252. Abstract

Zhang L, Meng S, Tu Q, Yu L, Tang Y, Dard MM, Kim SH, Valverde P, Zhou X, Chen J. 2014. Adiponectin ameliorates experimental periodontitis in diet-induced obesity mice. PLoS One 9: e97824. Abstract

Wu Y, Tu Q, Valverde P, Zhang J, Murray D, Dong L, Cheng J, Jiang H, Rios M, Morgan E, Tang Z, Chen J. 2014. Central adiponectin administration reveals new regulatory mechanisms of bone metabolism in mice. Am J Physiol Endocrinol Metab. 306: E1418-E1430. Abstract

Meng S, Zhang L, Tang Y, Tu Q, Zheng L, Yu L, Murray D, Cheng J, Kim SH, Zhou X, Chen J. 2014. BET inhibitor JQ1 blocks inflammation and bone destruction. J Dent Res. 93: 657-662. Abstract

Yan SG, Zhang J, Tu Q, Ye JH, Luo E, Schuler M, Dard MM, Yu Y, Murray D, Cochran DL, Kim SH, Yang P, Chen J. 2013. Transcription factor and bone marrow stromal cells in osseointegration of dental implants. Eur Cell Mater. 26: 263-271. Abstract

Luo E, Hu J, Bao C, Li Y, Tu Q, Murray D, Chen J. 2012. Sustained release of adiponectin improves osteogenesis around hydroxyapatite implants by suppressing osteoclast activity in ovariectomized rabbits. Acta Biomater. 8: 734-743. Abstract

Yan SG, Zhang J, Tu QS, Ye JH, Luo E, Schuler M, Kim MS, Griffin T, Zhao J, Duan XJ, Cochran DJ, Murray D, Yang PS, Chen J. 2011. Biomaterials. 32: 8676-8683. Abstract

Ye JH, Xu YJ, Gao J, Yan SG, Zhao J, Tu Q, Zhang J, Duan XJ, Sommer CA, Mostoslavsky G, Kaplan DL, Wu YN, Zhang CP, Wang L, Chen J. 2011. Critical-size calvarial bone defects healing in a mouse model with silk scaffolds and SATB2-modified iPSCs. Biomaterials. 32: 2065-5076. Abstract

Zhang J, Tu Q, Grosschedl R, Kim MS, Griffin T, Drissi H, Yang P, Chen J. 2011. Roles of SATB2 in osteogenic differentiation and bone regeneration. Tissue Eng Part A. 17: 1767-1776. Abstract

Zhang J, Tu Q, Bonewald LF, He X, Stein G, Lian J, Chen J. 2011. Effects of miR-335-5p in modulating osteogenic differentiation by specifically downregulating Wnt antagonist DKK1. J Bone Miner Res. 26: 1953-1963. Abstract

Tu Q, Zhang J, Dong LQ, Saunders E, Luo E, Tang J, Chen J. 2011. Adiponectin inhibits osteoclastogenesis and bone resorption via APPL1-mediated suppression of Akt1. J Biol Chem. 286: 12542-12553. Abstract

Duan X, Tu Q, Zhang J, Ye J, Sommer C, Mostoslavsky G, Kaplan D, Yang P, Chen J. 2011. Application of induced pluripotent stem (iPS) cells in periodontal tissue regeneration. J Cell Physiol. 226: 150-157. Abstract

Zhang J, Tu Q, Bonewald LF, He X, Stein G, Lian J, Chen J. 2011. Effects of miR-335-5p in modulating osteogenic differentiation by specifically down-regulating Wnt antagonist DKK1. J Bone Miner Res. 26: 1953-1963. Abstract

Tu Q, Zhang J, Saunders E, Liu F, Dong LQ and Chen, J. 2011. AKT1 is a downstream target of APPL1 mediating adiponectin signaling and inhibition in osteoclasts. J Biol Chem, 286: 12542-12553.

Zhang J, Tu Q, Grosschedl R, Kim MS, Griffin T, Drissi H, Yang P, Chen J. 2011. Roles of SATB2 in Osteogenic Differentiation and Bone Regeneration. Tissue Eng Part A. 17: 1767-1776. Abstract

Ye JH, Xu YJ, Gao J, Yan SG, Zhao J, Tu Q, Zhang J, Duan XJ, Sommer CA, Mostoslavsky G, Kaplan DL, Wu YN, Zhang CP, Wang L, Chen J. 2011. Critical-size calvarial bone defects healing in a mouse model with silk scaffolds and SATB2-modified iPSCs. Biomaterials 32: 5065-5076. Abstract