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Graduate School of Biomedical Sciences

Recent Publications from the Bullock Lab

Peterson JN, Lin B, Shin J, Phelan PJ, Tsichlis P, Schwob JE, Bullock PA. 2017. The Replication of JCV DNA in the G144 oligodendrocyte cell line is dependent upon Akt. J Virol. Epub ahead of print.  Abstract

Grubman SA, Shin J, Phelan PJ, Gong A, Can H, Dilworth R, Kini SK, Gagnon D, Archambault J, Meinke G, Bohm A, Jefferson DM, Bullock PA. 2016. Isolation of a monoclonal antibody that recognizes the origin binding domain of JCV, but not SV40, large T-antigen. Virology. 497: 92-101. Abstract

Meinke G, Phelan PJ, Shin J, Gagnon D, Archambault J, Bohm A, Bullock PA. 2016. Structural based analyses of the JC Virus T-antigen F258L mutant provides evidence for DNA dependent conformational changes in the C-termini of polyomavirus origin binding domains. PLoS Pathog. 12: e1005362.  Abstract

Shin J, Phelan PJ, Chhum P, Bashkenova N, Yim S, Parker R, Gagnon D, Gjoerup O, Archambault J, Bullock PA. 2014. Analysis of JC virus DNA replication using a quantitative and high-throughput assay. Virology 468-470: 113-125. Abstract

Meinke G, Phelan PJ, Kalekar R, Shin J, Archambault J, Bohm A, Bullock PA. 2014. Insights into the initiation of JC virus DNA replication derived from the crystal structure of the T-antigen origin binding domain. PLoS Pathog. 10: e1003966. Abstract

Meinke G, Phelan PJ, Harrison C, Bullock PA. 2013. Analysis of the co-structure of the SV40 T-antigen origin binding domain with Site I reveals a correlation GAGGC spacing and spiral assembly. J Virol. 87: 2923-2934. Abstract

Meinke G, Phelan P, Fradet-Turcotte A, Archambault J, Bullock PA. 2011. Structure-based design of a disulfide-linked oligomeric form of the simian virus 40 (SV40) large T antigen DNA-binding domain. Acta Crystallogr D Biol Crystallogr. 67: 560-567. Abstract

Harrison CJ, Meinke G, Kwun HJ, Rogalin H, Phelan PJ, Bullock PA, Chang Y, Moore PS, Bohm A. 2011. Asymmetric assembly of Merkel cell polyomavirus large T-antigen origin binding domains at the viral origin. J Mol Biol. 409: 529-42. Abstract

Meinke G, Bullock PA. 2011. Structural "snap-shots" of the initiation of SV40 replication. In Small DNA Tumor Viruses, K Gaston, ed, Horizon Scientific Press, Norwich, UK .

Meinke G, Phelan PJ, Fradet-Turcotte A, Bohm A, Archambault J, Bullock PA. 2011. Structure-based analysis of the interaction between the simian virus 40 T-antigen origin binding domain and single-stranded DNA. J Virol. 85: 818-827. Abstract