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Graduate School of Biomedical Sciences

Recent Publications from the Black Lab

Sood D, Cairns DM, Dabbi JM, Ramakrishnan C, Deisseroth K, Black LD 3rd, Santaniello S, Kaplan DL. 2019. Functional maturation of human neural stem cells in a 3D bioengineered brain model enriched with fetal brain-derived matrix. Sci Rep. 9(1):17874. doi: 10.1038/s41598-019-54248-1. Abstract

Sood D, Tang-Schomer M, Pouli D, Mizzoni C, Raia N, Tai A, Arkun K, Wu J, Black LD 3rd, Scheffler B, Georgakoudi I, Steindler DA, Kaplan DL. 2019. 3D extracellular matrix microenvironment in bioengineered tissue models of primary pediatric and adult brain tumors. Nat Commun. 10(1):4529. doi: 10.1038/s41467-019-12420-1. Abstract

Dasgupta Q, Black LD 3rd. 2019. A FRESH SLATE for 3D bioprinting. Science 365: 446-447. Abstract

Baugh LM, Watson MC, Kemmerling EC, Hinds P, Huggins GS, Black LD 3rd. 2019. Knockdown of CD44 expression decreases valve interstitial cell calcification in vitro. Am J Physiol Heart Circ Physiol 317: H26-H36. Abstract

Huang M, Liu Z, Baugh L, DeFuria J, Maione A, Smith A, Kashpur O, Black III LD, Georgakoudi I, Whitfield ML, Garlick J. 2018. Lysyl oxidase enzymes mediate TGF-β1-induced fibrotic phenotypes in human skin-like tissues. Lab Invest. 99: 514-527. Abstract

Daley MC, Fenn SL, Black LD 3rd. Applications of cardiac extracellular matrix in tissue engineering and regenerative medicine. Adv Exp Med Biol. 1098: 59-83. Abstract

Baugh LM, Liu Z, Quinn KP, Osseiran S, Evans CL, Huggins GS, Hinds PW, Black LD, Georgakoudi I. 2018. Non-destructive two-photon excited fluorescence imaging identifies early nodules in calcific aortic-valve disease. Nat Biomed Eng. 1: 914-924. Abstract

Freytsis M, Baugh L, Liu Z, Georgakoudi I, Hinds PW, Black LD, Huggins GS. 2018. Conditional deletion of RB1 in the Tie2 lineage leads to aortic valve regurgitation. PLoS One 13: e190623. Abstract

Sundarakrishnan A, Chen Y, Black LD, Aldridge BB, Kaplan DL. 2017. Engineered cell and tissue models of pulmonary fibrosis. Adv Drug Deliv Rev. 129: 78-94. Abstract

Quinn KP, Sullivan KE, Liu Z, Ballard Z, Siokatas C, Georgakoudi I, Black LD. 2016. Optical metrics of the extracellular matrix predict compositional and mechanical changes after myocardial infarction. Sci Rep. 6: 35823. Abstract

Stoppel WL, Gao AE, Greaney AM, Partlow BP, Bretherton RC, Kaplan DL, Black LD 3rd. 2016. Elastic, silk-cardiac extracellular matrix hydrogels exhibit time-dependent stiffening that modulates cardiac fibroblast response. J Biomed Mater Res A 104: 3058-3072.  Abstract

Gao AE, Sullivan KE, Black LD. 2016. Lysyl oxidase expression in cardiac fibroblasts is regulated by α2β1 integrin interactions with the cellular microenvironment. Biochim Biophys Acta. 475: 70-75   Abstract

Sullivan KE, Burns LJ, Black LD 3rd. 2015. An in vitro model for the assessment of stem cell fate following implantation within the infarct microenvironment identifies ISL-1 expression as the strongest predictor of c-Kit+ cardiac progenitor cells' therapeutic potential. J Mol Cell Cardiol. 88: 91-100.   Abstract

Stoppel WL, Kaplan DL, Black LD 3rd. 2015. Electrical and mechanical stimulation of cardiac cells and tissue constructs. Adv Drug Deliv Rev. pii: S0169-409X(15)00170-2.   Abstract

Williams C, Sullivan K, Black LD 3rd. 2015. Partially digested adult cardiac extracellular matrix promotes cardiomyocyte proliferation in vitro. Adv Healthc Mater. 4: 1545-1554. Abstract

Stoppel WL, Hu D, Domian IJ, Kaplan DL, Black LD. 2015. Anisotropic silk biomaterials containing cardiac extracellular matrix for cardiac tissue engineering. Biomed Mater. 10: 034105. Abstract

Stoppel WL, Ghezzi CE, McNamara SL, Black III LD, Kaplan DL. 2015. Clinical applications of naturally derived biopolymer-based scaffolds for regenerative medicine. Ann Biomed Eng. 43: 657-680. Abstract

Williams C, Budina E, Stoppel WL, Sullivan KE, Emani S, Emani SM, Black LD 3rd. 2015. Cardiac extracellular matrix-fibrin hybrid scaffolds with tunable properties for cardiovascular tissue engineering. Acta Biomater. 14: 84-89. Abstract

Lan JY, Williams C, Levin M, Black LD 3rd. 2014. Depolarization of cellular resting membrane potential promotes neonatal cardiomyocyte proliferation in vitro. Cell Mol Bioeng. 7: 432-445. Abstract

Gershlak JR, Black432-445. LD 3rd. 2014. β1 integrin binding Plays a role in the constant traction force generation in response to varying stiffness for Cells grown on mature cardiac extracellular matrix. Exp Cell Res. 330: 311-324. Abstract

Morgan KY, Black LD 3rd. 2014. Creation of a bioreactor for the application of variable amplitude mechanical stimulation of fibrin gel-based engineered cardiac tissue. Methods Mol Biol. 1181: 177-187. Abstract

Morgan KY, Black LD 3rd. 2014. Investigation into the effects of varying frequency of mechanical stimulation in a cycle-by-cycle manner on engineered cardiac construct function. J Tissue Eng Regen Med. 11: 342-353. Abstract

Morgan KY, Black LD 3rd. 2014. It's all in the timing: Modeling isovolumic contraction through development and disease with a dynamic dual electromechanical bioreactor system. Organogenesis 10: 317-322. Abstract

Lau JJ, Wang RM, Black LD 3rd. 2014. Development of an arbitrary waveform membrane stretcher for dynamic cell culture. Ann Biomed Eng. 42: 1062-1073. Abstract

Morgan KY, Black LD 2014. Mimicking isovolumic contraction with combined electromechanical stimulation improves the development of engineered cardiac constructs. Tissue Eng Part A 20: 1654-1657. Abstract

Twardowski RL, Black LD 3rd. 2014. Cardiac fibroblasts support endothelial cell proliferation and sprout formation but not the development of multicellular sprouts in a fibrin gel co-culture model. Ann Biomed Eng. 42: 1074-1084. Abstract

Williams C, Quinn KP, Georgakoudi I, Black LD 3rd. 2014. Young developmental age cardiac extracellular matrix promotes the expansion of neonatal cardiomyocytes in vitro. Acta Biomater. 10: 194-204. Abstract

Sullivan KE, Black LD. 2013. The role of cardiac fibroblasts in extracellular matrix-mediated signaling during normal and pathological cardiac development. J Biomech Eng. 135: 71001. Abstract

Gershlak JR, Resnikoff JI, Sullivan KE, Williams C, Wang RM, Black LD 3rd. 2013. Mesenchymal stem cells ability to generate traction stress in response to substrate stiffness is modulated by the changing extracellular matrix composition of the heart during development. Biochem Biophys Res Commun. 439: 161-166. Abstract